EVX2_HUMAN
ID EVX2_HUMAN Reviewed; 476 AA.
AC Q03828;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Homeobox even-skipped homolog protein 2;
DE AltName: Full=EVX-2;
GN Name=EVX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-300.
RX PubMed=1675198; DOI=10.1016/0888-7543(91)90482-t;
RA D'Esposito M., Morelli F., Acampora D., Migliaccio E., Simeone A.,
RA Boncinelli E.;
RT "EVX2, a human homeobox gene homologous to the even-skipped segmentation
RT gene, is localized at the 5' end of HOX4 locus on chromosome 2.";
RL Genomics 10:43-50(1991).
CC -!- INTERACTION:
CC Q03828; P59826: BPIFB3; NbExp=3; IntAct=EBI-17280301, EBI-1055244;
CC Q03828; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-17280301, EBI-12819063;
CC Q03828; Q99766-3: DMAC2L; NbExp=3; IntAct=EBI-17280301, EBI-13309711;
CC Q03828; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-17280301, EBI-11028396;
CC Q03828; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-17280301, EBI-1048945;
CC Q03828; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-17280301, EBI-10241353;
CC Q03828; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-17280301, EBI-12111050;
CC Q03828; Q14847-2: LASP1; NbExp=3; IntAct=EBI-17280301, EBI-9088686;
CC Q03828; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-17280301, EBI-12030590;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed during early embryogenesis and
CC neurogenesis in a biphasic manner.
CC -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
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DR EMBL; AC009336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M59983; AAA52414.1; -; Genomic_DNA.
DR EMBL; M59982; AAA52414.1; JOINED; Genomic_DNA.
DR CCDS; CCDS33333.1; -.
DR PIR; A39065; A39065.
DR RefSeq; NP_001073927.1; NM_001080458.1.
DR AlphaFoldDB; Q03828; -.
DR SMR; Q03828; -.
DR BioGRID; 131293; 9.
DR IntAct; Q03828; 9.
DR STRING; 9606.ENSP00000312385; -.
DR BioMuta; EVX2; -.
DR DMDM; 12231013; -.
DR MassIVE; Q03828; -.
DR PaxDb; Q03828; -.
DR PeptideAtlas; Q03828; -.
DR PRIDE; Q03828; -.
DR ProteomicsDB; 58223; -.
DR Antibodypedia; 19511; 147 antibodies from 23 providers.
DR DNASU; 344191; -.
DR Ensembl; ENST00000308618.5; ENSP00000312385.4; ENSG00000174279.5.
DR GeneID; 344191; -.
DR KEGG; hsa:344191; -.
DR MANE-Select; ENST00000308618.5; ENSP00000312385.4; NM_001080458.2; NP_001073927.1.
DR UCSC; uc010zeu.3; human.
DR CTD; 344191; -.
DR DisGeNET; 344191; -.
DR GeneCards; EVX2; -.
DR HGNC; HGNC:3507; EVX2.
DR HPA; ENSG00000174279; Tissue enhanced (brain, prostate, seminal vesicle, testis, vagina).
DR MIM; 142991; gene.
DR neXtProt; NX_Q03828; -.
DR OpenTargets; ENSG00000174279; -.
DR PharmGKB; PA27920; -.
DR VEuPathDB; HostDB:ENSG00000174279; -.
DR eggNOG; KOG0844; Eukaryota.
DR GeneTree; ENSGT00940000161025; -.
DR HOGENOM; CLU_045075_0_0_1; -.
DR InParanoid; Q03828; -.
DR OMA; KKTGHYS; -.
DR OrthoDB; 836887at2759; -.
DR PhylomeDB; Q03828; -.
DR TreeFam; TF315938; -.
DR PathwayCommons; Q03828; -.
DR SignaLink; Q03828; -.
DR BioGRID-ORCS; 344191; 16 hits in 1095 CRISPR screens.
DR GenomeRNAi; 344191; -.
DR Pharos; Q03828; Tbio.
DR PRO; PR:Q03828; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q03828; protein.
DR Bgee; ENSG00000174279; Expressed in calcaneal tendon and 15 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0035108; P:limb morphogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..476
FT /note="Homeobox even-skipped homolog protein 2"
FT /id="PRO_0000048872"
FT DNA_BIND 188..247
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 82..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 47800 MW; 6AA99041BA151C3F CRC64;
MMERIRKEMI LMERGLHSPT AGKRFSNLSN SAGNAVLEAL ENSQHPARLS PRLPSAPLHS
ALGELPAKGK FEIDTLFNLQ HTGSESTVSS EISSAAESRK KPGHYSEAAA EADMSSDVEV
GCSALRSPGG LGAAQLKENN GKGYAESGSA AGTTTSASGS GLGSLHGGSG GSGGSAALGG
SGSGADQVRR YRTAFTREQI ARLEKEFYRE NYVSRPRRCE LAAALNLPET TIKVWFQNRR
MKDKRQRLAM SWPHPADPSF YTYMMTHAAA TGSLPYPFHS HVPLHYYPHV GVTAAAAAAA
ASGAAAAASS PFATSIRPLD TFRALSHPYS RPELLCSFRH PGLYQAPAAA AGLNSAASAA
AAAAAAAAAA SSAAAAGAPP SGGSAPCSCL SCHSSQSAAA AAAAAAAALG SRGGGGGGGG
GGGGGGGGAG AGGGSDFGCS AAAPRSESGF LPYSAAVLSK TAVSPPDQRD EAPLTR
