ID   EVX2_MOUSE              Reviewed;         475 AA.
AC   P49749;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Homeobox even-skipped homolog protein 2;
DE   AltName: Full=EVX-2;
GN   Name=Evx2; Synonyms=Evx-2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1349539; DOI=10.1016/0012-1606(92)90232-6;
RA   Dush M.K., Martin G.R.;
RT   "Analysis of mouse Evx genes: Evx-1 displays graded expression in the
RT   primitive streak.";
RL   Dev. Biol. 151:273-287(1992).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S34322; AAB22138.1; -; Genomic_DNA.
DR   EMBL; S34320; AAB22138.1; JOINED; Genomic_DNA.
DR   EMBL; S34321; AAB22138.1; JOINED; Genomic_DNA.
DR   EMBL; M93128; AAA37585.1; -; mRNA.
DR   CCDS; CCDS16138.1; -.
DR   PIR; A43915; A43915.
DR   RefSeq; NP_031993.1; NM_007967.3.
DR   RefSeq; XP_006498791.1; XM_006498728.3.
DR   RefSeq; XP_006498792.1; XM_006498729.3.
DR   AlphaFoldDB; P49749; -.
DR   STRING; 10090.ENSMUSP00000134131; -.
DR   PaxDb; P49749; -.
DR   PRIDE; P49749; -.
DR   ProteomicsDB; 271508; -.
DR   Antibodypedia; 19511; 147 antibodies from 23 providers.
DR   DNASU; 14029; -.
DR   Ensembl; ENSMUST00000173623; ENSMUSP00000134131; ENSMUSG00000001815.
DR   GeneID; 14029; -.
DR   KEGG; mmu:14029; -.
DR   UCSC; uc008kdt.1; mouse.
DR   CTD; 344191; -.
DR   MGI; MGI:95462; Evx2.
DR   VEuPathDB; HostDB:ENSMUSG00000001815; -.
DR   eggNOG; KOG0844; Eukaryota.
DR   GeneTree; ENSGT00940000161025; -.
DR   HOGENOM; CLU_045075_0_0_1; -.
DR   InParanoid; P49749; -.
DR   OMA; KKTGHYS; -.
DR   OrthoDB; 836887at2759; -.
DR   PhylomeDB; P49749; -.
DR   TreeFam; TF315938; -.
DR   BioGRID-ORCS; 14029; 1 hit in 71 CRISPR screens.
DR   PRO; PR:P49749; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P49749; protein.
DR   Bgee; ENSMUSG00000001815; Expressed in neural tube marginal layer and 75 other tissues.
DR   ExpressionAtlas; P49749; baseline and differential.
DR   Genevisible; P49749; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0035108; P:limb morphogenesis; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Homeobox even-skipped homolog protein 2"
FT                   /id="PRO_0000048873"
FT   DNA_BIND        191..250
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          82..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  47902 MW;  2621C6059C76A798 CRC64;
     MMERIRKEMI LMERGLHSPT AGKRFSSLSD SAGGAVLEAL ENSQHPARLS PRLPSAPLHG
     ALGDLPAKGK FEIDTLFNLQ HPSSESTVSS EIASATESRK KPSHYSEAAA EADMSSDVEV
     GCSALRSPSG LGAAPLKENN AKGYTESGSV AGTTTSASGS GLGSLHGGGG GGNSGAAALG
     GSGSGSGADQ VRRYRTAFTR EQIARLEKEF YRENYVSRPR RCELAAALNL PETTIKVWFQ
     NRRMKDKRQR LAMSWPHPAD PSFYTYMMTH AAATGSLPYP FHSHVPLHYY PHVGVTAAAA
     AAAASGAAAA ASSPFATSIR PLDTFRALSH PYSRPELLCS FRHPGLYQAP AAAAGLNSAA
     SAAAAAAAAA AAASSAAAAG APPSGSSAPC SCLSCHSSQS AAAAAAAAAA ALGSRGGGGS
     GGGGGGGAGT AGGSDFGCSA AAPRSESGFL PYSAAVLSKT AVSPPDQRDE APLTR