EX3L1_HUMAN
ID EX3L1_HUMAN Reviewed; 746 AA.
AC Q86VI1; A8K7I9; Q8NAD2; Q8TEN2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Exocyst complex component 3-like protein;
DE AltName: Full=Protein Jiangli;
GN Name=EXOC3L1; Synonyms=EXOC3L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shan Y.X., Jiang L., Yu L.;
RT "Cloning and characterization of Jiangli gene.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-746.
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
RN [6]
RP VARIANTS [LARGE SCALE ANALYSIS] ASN-75 AND ASP-514.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: As part of the exocyst, may play a role in regulated
CC exocytosis of insulin granules. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with EXOC2, EXOC4 and EXOC5; may be part of the
CC exocyst. {ECO:0000250}.
CC -!- INTERACTION:
CC Q86VI1; Q8N4G2: ARL14; NbExp=3; IntAct=EBI-2813180, EBI-3921493;
CC Q86VI1; P40199: CEACAM6; NbExp=3; IntAct=EBI-2813180, EBI-4314501;
CC Q86VI1; O14964: HGS; NbExp=3; IntAct=EBI-2813180, EBI-740220;
CC Q86VI1; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-2813180, EBI-3044087;
CC Q86VI1; O43679: LDB2; NbExp=3; IntAct=EBI-2813180, EBI-2865580;
CC Q86VI1; P15172: MYOD1; NbExp=3; IntAct=EBI-2813180, EBI-488878;
CC Q86VI1; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-2813180, EBI-1105213;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000250}. Note=Colocalizes with insulin granules. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AY255669; AAP12545.1; -; mRNA.
DR EMBL; AK092858; BAC03991.1; -; mRNA.
DR EMBL; AK292004; BAF84693.1; -; mRNA.
DR EMBL; AC040160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83092.1; -; Genomic_DNA.
DR EMBL; AK074090; BAB84916.1; -; mRNA.
DR CCDS; CCDS10832.1; -.
DR RefSeq; NP_848611.2; NM_178516.3.
DR AlphaFoldDB; Q86VI1; -.
DR SMR; Q86VI1; -.
DR BioGRID; 129683; 30.
DR IntAct; Q86VI1; 8.
DR STRING; 9606.ENSP00000325674; -.
DR iPTMnet; Q86VI1; -.
DR PhosphoSitePlus; Q86VI1; -.
DR BioMuta; EXOC3L1; -.
DR DMDM; 223590205; -.
DR MassIVE; Q86VI1; -.
DR PaxDb; Q86VI1; -.
DR PeptideAtlas; Q86VI1; -.
DR PRIDE; Q86VI1; -.
DR ProteomicsDB; 70022; -.
DR Antibodypedia; 29440; 72 antibodies from 17 providers.
DR DNASU; 283849; -.
DR Ensembl; ENST00000314586.11; ENSP00000325674.6; ENSG00000179044.16.
DR GeneID; 283849; -.
DR KEGG; hsa:283849; -.
DR MANE-Select; ENST00000314586.11; ENSP00000325674.6; NM_178516.4; NP_848611.2.
DR UCSC; uc002erx.1; human.
DR CTD; 283849; -.
DR DisGeNET; 283849; -.
DR GeneCards; EXOC3L1; -.
DR HGNC; HGNC:27540; EXOC3L1.
DR HPA; ENSG00000179044; Tissue enriched (lymphoid).
DR MIM; 614117; gene.
DR neXtProt; NX_Q86VI1; -.
DR OpenTargets; ENSG00000179044; -.
DR PharmGKB; PA147031724; -.
DR VEuPathDB; HostDB:ENSG00000179044; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR HOGENOM; CLU_016260_3_0_1; -.
DR InParanoid; Q86VI1; -.
DR OMA; EQEPNTD; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q86VI1; -.
DR TreeFam; TF314979; -.
DR PathwayCommons; Q86VI1; -.
DR SignaLink; Q86VI1; -.
DR BioGRID-ORCS; 283849; 16 hits in 1067 CRISPR screens.
DR ChiTaRS; EXOC3L1; human.
DR GeneWiki; EXOC3L; -.
DR GenomeRNAi; 283849; -.
DR Pharos; Q86VI1; Tdark.
DR PRO; PR:Q86VI1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q86VI1; protein.
DR Bgee; ENSG00000179044; Expressed in spleen and 91 other tissues.
DR ExpressionAtlas; Q86VI1; baseline and differential.
DR Genevisible; Q86VI1; HS.
DR GO; GO:0000145; C:exocyst; ISS:UniProtKB.
DR GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR GO; GO:0030072; P:peptide hormone secretion; ISS:UniProtKB.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Exocytosis; Reference proteome.
FT CHAIN 1..746
FT /note="Exocyst complex component 3-like protein"
FT /id="PRO_0000309474"
FT REGION 1..370
FT /note="Mediates interaction with EXOC2, EXOC4 and EXOC5"
FT /evidence="ECO:0000250"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 75
FT /note="Y -> N (in a breast cancer sample; somatic mutation;
FT dbSNP:rs117403380)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_037002"
FT VARIANT 514
FT /note="A -> D (in a breast cancer sample; somatic mutation;
FT dbSNP:rs142958191)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_037003"
FT VARIANT 561
FT /note="Q -> E (in dbSNP:rs9939768)"
FT /id="VAR_036959"
FT VARIANT 634
FT /note="S -> G (in dbSNP:rs16957212)"
FT /id="VAR_036960"
FT CONFLICT 187
FT /note="V -> F (in Ref. 5; BAB84916)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="S -> G (in Ref. 1; AAP12545 and 5; BAB84916)"
FT /evidence="ECO:0000305"
FT CONFLICT 701..707
FT /note="Missing (in Ref. 2; BAC03991)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 746 AA; 81678 MW; C762DE3E63D782C9 CRC64;
MDSAAKDEMQ PALSPGPEWP EQERAEQLAR GAALKWASGI FYRPEQLARL GQYRSREVQR
TCSLESRLKS VMQSYLEGVQ TGVWQLAQAI EVVQGTREAL SQARGLLQGM SQALQTLEPL
RERVAQHKQL QALSHLLPRL RAVPAAVSHT QTLIDGQQFL EAYVSLRELE QLREDTWAPL
GGLELPVFQG LDLLFEALGQ AVEAAAGAAG KLAREDPALL VAAVRVAEVE TGRTTPLGQV
PRDWRQRCLR ALQEGLEQAH FGSPLLPAPG ALPGWLEALR VALPVELATA EALVAPCCPP
QYNVVQLWAH TLHSGLRRSL QNLLAGPELE AADAFALLHW ALHVYLGQEM MGSLELGPEA
DVSQLEPLLT LENIEQLEAT FVANIQASVS QWLQNALDGE VAEWGREHGP NTDPSGSYYS
PMPAIVLQIL EENIRVASLV SESLQQRVHG MALSELGTFL RSFSDALIRF SRDHFRGKSM
APHYVPYLLA ALNHKSALSS SVSVLQLDGA PSGALAPVEA ALDELQRRIY RLVLEALQAE
LQPLFADLPS RQWLSSPELL QSVCERTGRF CRDFWRVRNP TVQLLLAEAE RAVVLQYLSA
LMQGRLVCRG ADERTQAAER LRHDAAQLQQ LFLSLGLEEN AHCAPVLLAL RELLNLRDPA
LLGLEVAGLR QQFPDVSEDH VSALLGLRGD LSREQHLAAL SSLQAALPPS PRASRRVLFS
LVPAPALAPA SCLPSGSCAR ALLLAE
