EX3L1_MOUSE
ID EX3L1_MOUSE Reviewed; 739 AA.
AC Q8BI71; Q3USB8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Exocyst complex component 3-like protein;
GN Name=Exoc3l1; Synonyms=Exoc3l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EXOC2; EXOC4 AND EXOC5,
RP AND TISSUE SPECIFICITY.
RX PubMed=18480549; DOI=10.2220/biomedres.29.85;
RA Saito T., Shibasaki T., Seino S.;
RT "Involvement of Exoc3l, a protein structurally related to the exocyst
RT subunit Sec6, in insulin secretion.";
RL Biomed. Res. 29:85-91(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: As part of the exocyst, may play a role in regulated
CC exocytosis of insulin granules. {ECO:0000269|PubMed:18480549}.
CC -!- SUBUNIT: Interacts with EXOC2, EXOC4 and EXOC5; may be part of the
CC exocyst. {ECO:0000269|PubMed:18480549}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000269|PubMed:18480549}. Note=Colocalizes with insulin granules.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:18480549}.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK050100; BAC34066.1; -; mRNA.
DR EMBL; AK140526; BAE24415.1; -; mRNA.
DR EMBL; BC094238; AAH94238.1; -; mRNA.
DR CCDS; CCDS22597.1; -.
DR RefSeq; NP_808456.1; NM_177788.4.
DR RefSeq; XP_006531133.1; XM_006531070.3.
DR AlphaFoldDB; Q8BI71; -.
DR SMR; Q8BI71; -.
DR STRING; 10090.ENSMUSP00000053766; -.
DR iPTMnet; Q8BI71; -.
DR PhosphoSitePlus; Q8BI71; -.
DR MaxQB; Q8BI71; -.
DR PaxDb; Q8BI71; -.
DR PRIDE; Q8BI71; -.
DR ProteomicsDB; 271510; -.
DR Antibodypedia; 29440; 72 antibodies from 17 providers.
DR DNASU; 277978; -.
DR Ensembl; ENSMUST00000057855; ENSMUSP00000053766; ENSMUSG00000043251.
DR GeneID; 277978; -.
DR KEGG; mmu:277978; -.
DR UCSC; uc009nci.1; mouse.
DR CTD; 277978; -.
DR MGI; MGI:3041195; Exoc3l.
DR VEuPathDB; HostDB:ENSMUSG00000043251; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR HOGENOM; CLU_016260_3_0_1; -.
DR InParanoid; Q8BI71; -.
DR OMA; EQEPNTD; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q8BI71; -.
DR TreeFam; TF314979; -.
DR BioGRID-ORCS; 277978; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Exoc3l; mouse.
DR PRO; PR:Q8BI71; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BI71; protein.
DR Bgee; ENSMUSG00000043251; Expressed in yolk sac and 71 other tissues.
DR ExpressionAtlas; Q8BI71; baseline and differential.
DR Genevisible; Q8BI71; MM.
DR GO; GO:0000145; C:exocyst; IDA:UniProtKB.
DR GO; GO:0030141; C:secretory granule; IDA:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IDA:UniProtKB.
DR GO; GO:0030072; P:peptide hormone secretion; IDA:UniProtKB.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Exocytosis; Reference proteome.
FT CHAIN 1..739
FT /note="Exocyst complex component 3-like protein"
FT /id="PRO_0000309475"
FT REGION 1..370
FT /note="Mediates interaction with EXOC2, EXOC4 and EXOC5"
FT /evidence="ECO:0000269|PubMed:18480549"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 81204 MW; 22C9DBED29D8DC31 CRC64;
MDSKIQPTLR PGSSCPRPEW PEQERAEQLA RGAALKWASG IFYRPEQLTR LGQYRSREIQ
RNYSLEARIK SVVQSYLEGV QTGVWQLTRA LEAVQGTREA LSQAHHLLKG LSRTSQTLEP
LRECVVQHKQ LQILTRLLPR LQAVPATVAH TQTLIDSERL LEAYVSLREL EQLKEETLAP
LGGLELPIFQ GLGLLAEALG QAVEAAAGAA GRLAREDPAL LVAAIRVAEV ETERTILGQA
PRDWRQRCLR ALQEGLERVH FASPVLPEPG ALAGWLEALQ VALPAELATA EALVAPCCPP
SYRVVELWAH TLHSGLRRSV QQLLAGPELG AADTFALLHW ALHVYTGKEM MGNLELGPEA
DVSQLEPLLT SENIEQLEAA FVAQVQVSVA QWLKKALDGE VAEWSGEQEP PTDPSGFYHS
PMPAIVLQIL AENIQVTNLI SDSLHRRAHN MAVSELGAFL RSFSDALIRF SRDHLRGDAV
APHYVPYLLS AFNHQSALRS SVSVLLPDGE ASGVLAPVEA ALDDVQRRIC RLVLEVLQVE
LQPLFSALPS RRWLLSSELL DGVCEQTSHF CQDFWRVRKP GVQLLLAEAE RTVVLQYLRA
LMQGRLVCRG TDERSQAAER LRQDAAQLKE LFLGLGLEES AHCAPVLLAL RELLNLHDPT
LLGLEVAGLR QQFPDVSEDH VSALLDLRGD VSREHRQAAL SSLQAGPPPS PSTGRRALFS
LVPTPTPSLS SCLPSGPCS
