EX3L2_HUMAN
ID EX3L2_HUMAN Reviewed; 409 AA.
AC Q2M3D2; Q8N9W2; Q96GV2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Exocyst complex component 3-like protein 2;
DE AltName: Full=HBV X-transactivated gene 7 protein;
DE AltName: Full=HBV XAg-transactivated protein 7;
GN Name=EXOC3L2; Synonyms=XTP7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 215-409.
RA Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.;
RT "Cloning and identification of human gene 7 transactivated by hepatitis B
RT virus X antigen.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q2M3D2; Q13323: BIK; NbExp=3; IntAct=EBI-14890134, EBI-700794;
CC Q2M3D2; Q8TDV2: GPR148; NbExp=3; IntAct=EBI-14890134, EBI-17294222;
CC Q2M3D2; P52815: MRPL12; NbExp=3; IntAct=EBI-14890134, EBI-358272;
CC Q2M3D2; Q9UNG2: TNFSF18; NbExp=3; IntAct=EBI-14890134, EBI-15672281;
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AK093466; BAC04175.1; -; mRNA.
DR EMBL; CH471126; EAW57331.1; -; Genomic_DNA.
DR EMBL; BC104947; AAI04948.1; -; mRNA.
DR EMBL; BC104949; AAI04950.1; -; mRNA.
DR EMBL; AF490256; AAO85464.1; -; mRNA.
DR RefSeq; NP_612635.3; NM_138568.3.
DR AlphaFoldDB; Q2M3D2; -.
DR SMR; Q2M3D2; -.
DR BioGRID; 124695; 39.
DR IntAct; Q2M3D2; 8.
DR STRING; 9606.ENSP00000400713; -.
DR iPTMnet; Q2M3D2; -.
DR PhosphoSitePlus; Q2M3D2; -.
DR SwissPalm; Q2M3D2; -.
DR BioMuta; EXOC3L2; -.
DR DMDM; 121941479; -.
DR jPOST; Q2M3D2; -.
DR MassIVE; Q2M3D2; -.
DR MaxQB; Q2M3D2; -.
DR PaxDb; Q2M3D2; -.
DR PeptideAtlas; Q2M3D2; -.
DR PRIDE; Q2M3D2; -.
DR ProteomicsDB; 61373; -.
DR DNASU; 90332; -.
DR GeneID; 90332; -.
DR UCSC; uc002pay.1; human.
DR CTD; 90332; -.
DR DisGeNET; 90332; -.
DR GeneCards; EXOC3L2; -.
DR HGNC; HGNC:30162; EXOC3L2.
DR neXtProt; NX_Q2M3D2; -.
DR PharmGKB; PA162385462; -.
DR eggNOG; KOG2286; Eukaryota.
DR HOGENOM; CLU_057346_0_0_1; -.
DR InParanoid; Q2M3D2; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q2M3D2; -.
DR TreeFam; TF314979; -.
DR PathwayCommons; Q2M3D2; -.
DR SignaLink; Q2M3D2; -.
DR BioGRID-ORCS; 90332; 15 hits in 1076 CRISPR screens.
DR ChiTaRS; EXOC3L2; human.
DR GenomeRNAi; 90332; -.
DR Pharos; Q2M3D2; Tbio.
DR PRO; PR:Q2M3D2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q2M3D2; protein.
DR Genevisible; Q2M3D2; HS.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..409
FT /note="Exocyst complex component 3-like protein 2"
FT /id="PRO_0000309477"
FT COILED 254..280
FT /evidence="ECO:0000255"
FT VARIANT 173
FT /note="N -> D (in dbSNP:rs10411314)"
FT /id="VAR_036961"
FT CONFLICT 264
FT /note="A -> S (in Ref. 1; BAC04175)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 45859 MW; E37550F7628F332B CRC64;
MAALENGELG PLLSPGTLRG LEDECVTDVK AQTRAALLRV LQEDEEHWGS LEDQPSSLAQ
DVCELLEEHT ERAPRISQEF GERMAHCCLG GLAEFLQSFQ QRVERFHENP AVREMLPDTY
ISKTIALVNC GPPLRALAER LARVGPPESE PAREASASAL DHVTRLCHRV VANLLFQELQ
PHFNKLMRRK WLSSPEALDG IVGTLGAQAL ALRRMQDEPY QALVAELHRR ALVEYVRPLL
RGRLRCSSAR TRSRVAGRLR EDAAQLQRLF RRLESQASWL DAVVPHLAEV MQLEDTPSIQ
VEVGVLVRDY PDIRQKHVAA LLDIRGLRNT AARQEILAVA RDLELSEEGA LSPPRDRAFF
ADIPVPRPSF CLSLPLFLGR LPLSRLARPS LACLPRPRPP SLARPRAQR
