EX3L4_HUMAN
ID EX3L4_HUMAN Reviewed; 722 AA.
AC Q17RC7; Q14CR2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Exocyst complex component 3-like protein 4;
GN Name=EXOC3L4; Synonyms=C14orf73;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS TRP-77; GLU-93;
RP HIS-185 AND GLU-685.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AL161669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113655; AAI13656.1; -; mRNA.
DR EMBL; BC117375; AAI17376.1; -; mRNA.
DR CCDS; CCDS32163.1; -.
DR RefSeq; NP_001071062.1; NM_001077594.1.
DR RefSeq; XP_011535627.1; XM_011537325.2.
DR RefSeq; XP_011535629.1; XM_011537327.2.
DR RefSeq; XP_011535630.1; XM_011537328.2.
DR RefSeq; XP_011535631.1; XM_011537329.2.
DR RefSeq; XP_011535632.1; XM_011537330.2.
DR RefSeq; XP_011535633.1; XM_011537331.1.
DR RefSeq; XP_011535634.1; XM_011537332.2.
DR AlphaFoldDB; Q17RC7; -.
DR SMR; Q17RC7; -.
DR BioGRID; 124883; 3.
DR STRING; 9606.ENSP00000369409; -.
DR GlyGen; Q17RC7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q17RC7; -.
DR PhosphoSitePlus; Q17RC7; -.
DR SwissPalm; Q17RC7; -.
DR BioMuta; EXOC3L4; -.
DR DMDM; 290457635; -.
DR EPD; Q17RC7; -.
DR jPOST; Q17RC7; -.
DR MassIVE; Q17RC7; -.
DR MaxQB; Q17RC7; -.
DR PaxDb; Q17RC7; -.
DR PeptideAtlas; Q17RC7; -.
DR PRIDE; Q17RC7; -.
DR ProteomicsDB; 61146; -.
DR Antibodypedia; 49636; 11 antibodies from 7 providers.
DR DNASU; 91828; -.
DR Ensembl; ENST00000380069.7; ENSP00000369409.3; ENSG00000205436.8.
DR Ensembl; ENST00000687959.1; ENSP00000508483.1; ENSG00000205436.8.
DR Ensembl; ENST00000688303.1; ENSP00000509130.1; ENSG00000205436.8.
DR GeneID; 91828; -.
DR KEGG; hsa:91828; -.
DR MANE-Select; ENST00000688303.1; ENSP00000509130.1; NM_001077594.2; NP_001071062.1.
DR UCSC; uc001ymk.4; human.
DR CTD; 91828; -.
DR DisGeNET; 91828; -.
DR GeneCards; EXOC3L4; -.
DR HGNC; HGNC:20120; EXOC3L4.
DR HPA; ENSG00000205436; Group enriched (intestine, liver).
DR neXtProt; NX_Q17RC7; -.
DR OpenTargets; ENSG00000205436; -.
DR PharmGKB; PA134980508; -.
DR VEuPathDB; HostDB:ENSG00000205436; -.
DR eggNOG; KOG2286; Eukaryota.
DR GeneTree; ENSGT01030000234613; -.
DR HOGENOM; CLU_023686_0_0_1; -.
DR InParanoid; Q17RC7; -.
DR OMA; MDVHMLV; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q17RC7; -.
DR TreeFam; TF314979; -.
DR PathwayCommons; Q17RC7; -.
DR BioGRID-ORCS; 91828; 13 hits in 1076 CRISPR screens.
DR GenomeRNAi; 91828; -.
DR Pharos; Q17RC7; Tdark.
DR PRO; PR:Q17RC7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q17RC7; protein.
DR Bgee; ENSG00000205436; Expressed in right lobe of liver and 119 other tissues.
DR ExpressionAtlas; Q17RC7; baseline and differential.
DR Genevisible; Q17RC7; HS.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..722
FT /note="Exocyst complex component 3-like protein 4"
FT /id="PRO_0000274380"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 513
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 77
FT /note="R -> W (in dbSNP:rs2297067)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030273"
FT VARIANT 93
FT /note="D -> E (in dbSNP:rs2297066)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030274"
FT VARIANT 185
FT /note="L -> H (in dbSNP:rs10131298)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030275"
FT VARIANT 675
FT /note="Q -> R (in dbSNP:rs729184)"
FT /id="VAR_030276"
FT VARIANT 685
FT /note="Q -> E (in dbSNP:rs744153)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062863"
SQ SEQUENCE 722 AA; 79896 MW; 63768DCB8EB37990 CRC64;
MPSPQTDTPG PELQSPKEAE EPQTPAQGSR RTSSRKEPNA HRKDGTRLGL GSLRQAFSRA
SQRALTQVSK EDTGLFRRSS CSLFRSFRQA LNDGPATGHS QATPEVPSGV MNGVSQQAST
GAASEELKPE AEGKSVADLI TERQLLAAFE QLLRLETLLV AEKASRTFEQ DPTAFARRAM
DVCLLYDGLA AEIGAIVRET LDSDGVDAAA LAELARVVSA EEEAHPSPPD DGDFLRTPRR
WRQHWEEAVR RSAQERVRRP GAGWAFGEAE GASGLAQLLA ELGGLVRRDL QKVRQEVQPA
YAAAGFPAWE VYLRAFHSAV AQRLQELARD ARGCEQLYIL LDWAANVYGS PDFLGAPGLA
LPAEPLPPLL APDVWARLES DYTSFLEAKI ASCFDSILQL EQSHWAAAEV PEVLQGLYQA
PLSMDVHMLV AEHVKAAGAI SAELEATTLR ICTRALGLFV PRFEKAFLAS EAVSEPHLGA
YINACEELRT SLLSRFPGTQ EELEKPLVTA TCSFQKHLLQ GLQRELQPLF RVVCTRDWLT
QDWLHPLMDK VVTFAGHLQR VARPRAQETL QEVHRFVVRE YLARALRPRE RFRGMERMHG
SQKMSLDAQA ISDTFQGLGS EATWLDQAIQ CVAEILGETY KDDIQRHLET LIRSYPDIRR
DHILAILALR RLGRQRNQHL LQHTQDLLRA AAGAAGAEAP RGRVLFEEIK VPSAMAVLIT
CV
