EX3L4_MOUSE
ID EX3L4_MOUSE Reviewed; 721 AA.
AC Q6DIA2; Q80UY5; Q9DAX8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Exocyst complex component 3-like protein 4;
GN Name=Exoc3l4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Eye, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; AK005443; BAB24037.1; -; mRNA.
DR EMBL; BC042799; AAH42799.1; -; mRNA.
DR EMBL; BC075664; AAH75664.1; -; mRNA.
DR CCDS; CCDS26177.1; -.
DR RefSeq; NP_001276416.1; NM_001289487.1.
DR RefSeq; NP_001276417.1; NM_001289488.1.
DR RefSeq; NP_001276418.1; NM_001289489.1.
DR RefSeq; NP_083083.3; NM_028807.4.
DR RefSeq; XP_006516352.1; XM_006516289.2.
DR RefSeq; XP_006516354.1; XM_006516291.3.
DR RefSeq; XP_006516355.1; XM_006516292.3.
DR AlphaFoldDB; Q6DIA2; -.
DR SMR; Q6DIA2; -.
DR BioGRID; 216562; 1.
DR STRING; 10090.ENSMUSP00000072438; -.
DR iPTMnet; Q6DIA2; -.
DR PhosphoSitePlus; Q6DIA2; -.
DR MaxQB; Q6DIA2; -.
DR PaxDb; Q6DIA2; -.
DR PeptideAtlas; Q6DIA2; -.
DR PRIDE; Q6DIA2; -.
DR ProteomicsDB; 275554; -.
DR DNASU; 74190; -.
DR GeneID; 74190; -.
DR KEGG; mmu:74190; -.
DR UCSC; uc007pcv.2; mouse.
DR CTD; 91828; -.
DR MGI; MGI:1921363; Exoc3l4.
DR eggNOG; KOG2286; Eukaryota.
DR InParanoid; Q6DIA2; -.
DR OrthoDB; 391172at2759; -.
DR PhylomeDB; Q6DIA2; -.
DR TreeFam; TF314979; -.
DR BioGRID-ORCS; 74190; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q6DIA2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6DIA2; protein.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..721
FT /note="Exocyst complex component 3-like protein 4"
FT /id="PRO_0000274381"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 515
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q17RC7"
FT CONFLICT 258
FT /note="S -> R (in Ref. 1; BAB24037)"
FT /evidence="ECO:0000305"
FT CONFLICT 680
FT /note="Q -> H (in Ref. 2; AAH75664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 721 AA; 81035 MW; 00703209D717E32F CRC64;
MPLPQTGAPG PEVKSPREPR KSQTLPVTTW KSNSMKEQSV HHGGSLRPSL GMLKQTLFRT
SLRTSTHKPK EDPGLFRRSS RFLFRSLRRA IDEGLTAGHP QGPAVPEKPS KVTDGVSRQA
ATGTEAEDLE PQAESKSVAD LITERQLVKA FEQLRYLETQ LVADKTSRTF TQDPTAYARR
AMDLCLHYDG MAAEIGAIVR EALSSEGVDR DALAELAQVV HLEEEAHQTS QAEGDFLSTP
RHWRMHWEDA VRLSAQESVQ QAGAKVIPGA AEGSSDLAQL LAELGGVVRH DLQKVRLEMQ
PAYEATDFPV WETYLRAFHS AVAQRLQELA RDARGCEQLY VLLDWAANVY GSPDFLGAPD
LALPTEPLPP LLEPALWARL ESDYTSFLET KITSCFDSIL QLEQNRWEAD EDREVLQGLY
HAPLSIDVHM LVAEHVKAAG AISAELEATT LQICARALCL FVPRFEKAFL ASKAVSEWYL
GAYINACVEL RTSLLARFPG TIKELEKPLV AATNSFQKHL LQIVQQDMQP LFKVLYTKSW
LTQDTLRPLM DKVVDFAHHL EHVTPPLAQE TLQEVHRFVV REYLGQVLRP HERFSGQDRL
KGSNKMNLDA QAISNTFQGL GSEAKWLDQA ILSVAEILGE TYKDDIRRHL ETLIRSYPDI
RRDHILAILA LRRLGRRRNQ NLLQHTQDLL RAAHETRLPS HHVLFEEIEV PTSVDVLITC
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