EX53_ALKHC
ID EX53_ALKHC Reviewed; 303 AA.
AC Q9KAV6;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=5'-3' exonuclease;
DE EC=3.1.11.-;
GN OrderedLocusNames=BH2180;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC DNA. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000004; BAB05899.1; -; Genomic_DNA.
DR PIR; D83922; D83922.
DR RefSeq; WP_010898337.1; NC_002570.2.
DR AlphaFoldDB; Q9KAV6; -.
DR SMR; Q9KAV6; -.
DR STRING; 272558.10174799; -.
DR EnsemblBacteria; BAB05899; BAB05899; BAB05899.
DR KEGG; bha:BH2180; -.
DR eggNOG; COG0258; Bacteria.
DR HOGENOM; CLU_004675_1_5_9; -.
DR OMA; WRVDLIP; -.
DR OrthoDB; 1220182at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR038969; FEN.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR42646; PTHR42646; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SUPFAM; SSF47807; SSF47807; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 3: Inferred from homology;
KW DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..303
FT /note="5'-3' exonuclease"
FT /id="PRO_0000101281"
FT DOMAIN 179..262
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000255"
SQ SEQUENCE 303 AA; 34038 MW; 4EC4D4B9F245BA37 CRC64;
MHSPVLLLID GFNLLSRGYF ATSYGKDEAQ LPRNEAGYYI NALRVFFPKL FQLIREHNVT
HVAVAWDVKR EDSHRRQAFA FYKASRGELP EALIEQYETA TSLLEEIGVA QVTIPPYEAD
DTIGAFACRW AKEEKGHCFI YSNDRDLLQL LSKSTSQIIS SKGKDLIYTE ENFRNDYNIS
PAQWVDVKAL LGDKSDNIPG CPGVGEKSAL PLIQQYGTIE TLYEQIEDLD PKYKRYHKKL
VAGEESVIIS KELATITTEI EAISSFSLNS LVLTTPADLI IDTLARCGIR VKLAPVQTEL
KLG