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EX53_ALKHC
ID   EX53_ALKHC              Reviewed;         303 AA.
AC   Q9KAV6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   OrderedLocusNames=BH2180;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; BA000004; BAB05899.1; -; Genomic_DNA.
DR   PIR; D83922; D83922.
DR   RefSeq; WP_010898337.1; NC_002570.2.
DR   AlphaFoldDB; Q9KAV6; -.
DR   SMR; Q9KAV6; -.
DR   STRING; 272558.10174799; -.
DR   EnsemblBacteria; BAB05899; BAB05899; BAB05899.
DR   KEGG; bha:BH2180; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_5_9; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..303
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101281"
FT   DOMAIN          179..262
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   303 AA;  34038 MW;  4EC4D4B9F245BA37 CRC64;
     MHSPVLLLID GFNLLSRGYF ATSYGKDEAQ LPRNEAGYYI NALRVFFPKL FQLIREHNVT
     HVAVAWDVKR EDSHRRQAFA FYKASRGELP EALIEQYETA TSLLEEIGVA QVTIPPYEAD
     DTIGAFACRW AKEEKGHCFI YSNDRDLLQL LSKSTSQIIS SKGKDLIYTE ENFRNDYNIS
     PAQWVDVKAL LGDKSDNIPG CPGVGEKSAL PLIQQYGTIE TLYEQIEDLD PKYKRYHKKL
     VAGEESVIIS KELATITTEI EAISSFSLNS LVLTTPADLI IDTLARCGIR VKLAPVQTEL
     KLG
 
 
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