ID   EX53_AQUAE              Reviewed;         289 AA.
AC   O67550;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   OrderedLocusNames=aq_1628;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AE000657; AAC07515.1; -; Genomic_DNA.
DR   PIR; D70440; D70440.
DR   RefSeq; NP_214115.1; NC_000918.1.
DR   RefSeq; WP_010881053.1; NC_000918.1.
DR   AlphaFoldDB; O67550; -.
DR   SMR; O67550; -.
DR   STRING; 224324.aq_1628; -.
DR   EnsemblBacteria; AAC07515; AAC07515; aq_1628.
DR   KEGG; aae:aq_1628; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_0_0; -.
DR   InParanoid; O67550; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..289
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101280"
FT   DOMAIN          166..256
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   289 AA;  33322 MW;  7DC95E0BAF5D3C82 CRC64;
     MKTLYILDGS SFVYRSFFAL PPLSTSKGFP TNAIYGFLRM LFSLIKKERP QYLVVVFDAP
     AKTKREKIYA DYKKQRPKAP DPLKVQIPVI KEILKLAGIP LLELPGYEAD DVIAYLAEKF
     SQKGFKVKIY SPDKDLLQLV SENVLVINPM NDEVFTKERV IKKFGVEPQK IPDYLALVGD
     KVDNVPGIEG VGPKTAINIL KKYGSVENIL KNWEKFQREF PRAKKEDLEL SYKLVKLYTD
     LDIELSEEDL KIKRPDLNKL KQKLQELEMK SLLKEVDKIF RQASQRSLF