ID   EX53_BUCAP              Reviewed;         287 AA.
AC   Q8K9D0;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=pol; OrderedLocusNames=BUsg_416;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AE013218; AAM67961.1; -; Genomic_DNA.
DR   RefSeq; WP_011053928.1; NC_004061.1.
DR   AlphaFoldDB; Q8K9D0; -.
DR   SMR; Q8K9D0; -.
DR   STRING; 198804.BUsg_416; -.
DR   EnsemblBacteria; AAM67961; AAM67961; BUsg_416.
DR   KEGG; bas:BUsg_416; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_0_6; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..287
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101284"
FT   DOMAIN          172..270
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  33047 MW;  48E529C5D4B718E2 CRC64;
     MPYTKKKPII IVDGSLYLYR SYFTFQNFNS NEENPSGAIY GMLKTIQNIL NKNYNSKKII
     IIFDSSKKNF RNTIFKEYKS NRSAMPNKLY VQIQPLFKIL EEIGIKTLSI LGIEADDIIG
     SLAYKLEQKG EQVLIVSHDK DMIQLITDNI NVLNISKNSI LTPEKIQEKY GIYPKEFIDL
     LALMGDSSDN IPGVPKIGIK TALFLLKKFS NIKNIYNNIE KIQSLPFRNA KNAAIQLKNY
     KKTAFLSYQL AKIKLDVPIN ITSEEITLKK TCFKKLSNLI RWYSFNE