ID   EX53_BUCBP              Reviewed;         302 AA.
AC   Q89AD1;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=pol; OrderedLocusNames=bbp_382;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AE016826; AAO27094.1; -; Genomic_DNA.
DR   RefSeq; WP_011091495.1; NC_004545.1.
DR   AlphaFoldDB; Q89AD1; -.
DR   SMR; Q89AD1; -.
DR   STRING; 224915.bbp_382; -.
DR   EnsemblBacteria; AAO27094; AAO27094; bbp_382.
DR   GeneID; 56470919; -.
DR   KEGG; bab:bbp_382; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_0_6; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..302
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101285"
FT   DOMAIN          173..269
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  34883 MW;  ACD2B31AA67E6C75 CRC64;
     MIIYKKNVNY LLIDGTSYLY RAYYAFLKFK NNFNKPCGAI YGMLNMLRSM LLKYPYSNIV
     VIFDSPQKTF RNELFIPYKK NRPKMPNDLK EQILPIHHII KHIGIPIISI PHVEADDIIG
     TLATKLYKKK YFILISTNDK DLAQLVNIHI HVLIGTSNIV LDESKVKKKY GIIPKLIPDL
     LGLMGDNSDN IPGVPTVGKK TALILLKTFG SLENIYNNIE KIPKCLIKKA KTIYNNLHTY
     KKLAFLSQKL ATIKTDINVN ITTKKIKMLP PCTTEISNFF LHYKFYNWNK LLKQGLWLKN
     CK