ID   EX53_MYCGE              Reviewed;         291 AA.
AC   Q49406;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=polA; OrderedLocusNames=MG262;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L43967; AAC71483.1; -; Genomic_DNA.
DR   PIR; I64228; I64228.
DR   RefSeq; WP_010869399.1; NC_000908.2.
DR   AlphaFoldDB; Q49406; -.
DR   SMR; Q49406; -.
DR   STRING; 243273.MG_262; -.
DR   EnsemblBacteria; AAC71483; AAC71483; MG_262.
DR   KEGG; mge:MG_262; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_5_14; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   BioCyc; MGEN243273:G1GJ2-317-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..291
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101286"
FT   DOMAIN          176..269
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  33271 MW;  B026EFEFA1539CE7 CRC64;
     MKKAILIDGN SLAYRAYFAT WKQVEYAKQN NLPFNNAIRT MLLMCWNLIK ANVYQYGIVS
     FDTKAPTFRD QIYEGYKQKR VKTPVELLVQ IPLIKQALVY LGFLVCEKDG FEADDLIGSY
     ANLFTKQEIT VDIYSSDRDM LQLVNAFTNV FLCIKGTKEM VMYNNENFKS LFYGLAPYQV
     VEYKGLVGDN SDNLAGIKGI GPIKGIELLQ QYGTIDNIYT NFNNLPNQLQ KLLNNQKEIA
     KTFSFLAKIK TDIELDQNID LTGLKPIQKQ ALIQLLSENK INTLVEKFSK I