ID   EX53_MYCPN              Reviewed;         291 AA.
AC   P75403;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=polA; OrderedLocusNames=MPN_379; ORFNames=MP458;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; U00089; AAB96106.1; -; Genomic_DNA.
DR   PIR; S73784; S73784.
DR   RefSeq; NP_110067.1; NC_000912.1.
DR   RefSeq; WP_010874735.1; NC_000912.1.
DR   AlphaFoldDB; P75403; -.
DR   SMR; P75403; -.
DR   IntAct; P75403; 3.
DR   STRING; 272634.MPN_379; -.
DR   EnsemblBacteria; AAB96106; AAB96106; MPN_379.
DR   GeneID; 66608963; -.
DR   KEGG; mpn:MPN_379; -.
DR   PATRIC; fig|272634.6.peg.410; -.
DR   HOGENOM; CLU_004675_1_5_14; -.
DR   OMA; WRVDLIP; -.
DR   BioCyc; MPNE272634:G1GJ3-600-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..291
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101287"
FT   DOMAIN          176..269
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  32972 MW;  57940FA7F3D852EC CRC64;
     MKNAILIDGN SLAYRAYFAT WQQVEFAKLH NLPFNNAIRT MLMMCWNLLQ SKQYDYGVIS
     FDTKAPTFRD QLYSEYKSKR SKTPSELLVQ IPVVKESLRH LGFLVCEQDG FEADDLIGSY
     ARLMTQNNVA VDIYSSDRDL LQLVDSMTSV WLCVKGTKEM KEYNTDNFAE QFFGLTPKQV
     IEYKGLVGDN SDNLTGIKGI GPKKGIDLLK QYGTIDNIFA NFDKLSKALQ TILQGQIDTA
     KKFSFLASIK TDIKLNDDIV HAALKPIDKQ ALLELLDKYG IKALAQKFSQ L