ID   EX53_MYCPU              Reviewed;         297 AA.
AC   Q98PK2;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=polA; OrderedLocusNames=MYPU_7200;
OS   Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=272635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT   pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AL445565; CAC13893.1; -; Genomic_DNA.
DR   PIR; H90601; H90601.
DR   RefSeq; WP_010925521.1; NC_002771.1.
DR   AlphaFoldDB; Q98PK2; -.
DR   SMR; Q98PK2; -.
DR   STRING; 272635.MYPU_7200; -.
DR   EnsemblBacteria; CAC13893; CAC13893; CAC13893.
DR   KEGG; mpu:MYPU_7200; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_5_14; -.
DR   OMA; WRVDLIP; -.
DR   OrthoDB; 1220182at2; -.
DR   BioCyc; MPUL272635:G1GT6-733-MON; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..297
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101288"
FT   DOMAIN          171..262
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  34755 MW;  02BECA7C4FA1889D CRC64;
     MTKSGSKSEK FLLIDGNYLV HRSYYVSFKF KNNFRSTIYL FFQTIIKIIK NLNPENIFIA
     FDEEGGTWRH DLCKEYKSQR SKMEDEFWNI FKAIREILDS INLNSGGFRG HEADDVIATI
     TSKFKDENQI YIFSRDKDLL QLIDKNVYIT HDNELKNLIS IENFYQNFQL EPDQIVDFKA
     IAGDSSDNLK GIAGIGEKGA KNLLNNFKSL EKIFDSLEST NLISKAQKQK IRDGKEQALF
     LKKIVTLNKE VPMKLEKELF AIKININEEI LEKLDKYDSR YVLKQFEKAL ESDDYLW