ID   EX53_MYCTO              Reviewed;         318 AA.
AC   P9WNU2; L0TBC4; Q10699;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   OrderedLocusNames=MT2151;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AE000516; AAK46432.1; -; Genomic_DNA.
DR   PIR; E70767; E70767.
DR   RefSeq; WP_003410750.1; NC_002755.2.
DR   AlphaFoldDB; P9WNU2; -.
DR   SMR; P9WNU2; -.
DR   EnsemblBacteria; AAK46432; AAK46432; MT2151.
DR   KEGG; mtc:MT2151; -.
DR   HOGENOM; CLU_004675_1_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..318
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000427067"
FT   DOMAIN          194..278
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  33989 MW;  413985ECEC3361A9 CRC64;
     MRSPLVLLDG ASMWFRSFFG VPSSITAPDG RPVNAVRGFI DSMAVVITQQ RPNRLAVCLD
     LDWRPQFRVD LIPSYKAHRV AEPEPNGQPD VEEVPDELTP QVDMIMELLD AFGIAMAGAP
     GFEADDVLGT LATRERRDPV IVVSGDRDLL QVVADDPVPV RVLYLGRGLA KATLFGPAEV
     AERYGLPAHR AGAAYAELAL LRGDPSDGLP GVPGVGEKTA ATLLARHGSL DQIMAAADDR
     KTTMAKGLRT KLLAASAYIK AADRVVRVAT DAPVTLSTPT DRLPLVAADP ERTAELATRF
     GVESSIARLQ KALDTLPG