ID   EX53_STRCO              Reviewed;         301 AA.
AC   Q9RJ79;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   OrderedLocusNames=SCO1622; ORFNames=SCI41.05;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AL939109; CAB59475.1; -; Genomic_DNA.
DR   RefSeq; NP_625897.1; NC_003888.3.
DR   RefSeq; WP_011027889.1; NZ_VNID01000018.1.
DR   AlphaFoldDB; Q9RJ79; -.
DR   SMR; Q9RJ79; -.
DR   STRING; 100226.SCO1622; -.
DR   GeneID; 1097053; -.
DR   KEGG; sco:SCO1622; -.
DR   PATRIC; fig|100226.15.peg.1637; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_3_11; -.
DR   OMA; WRVDLIP; -.
DR   PhylomeDB; Q9RJ79; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..301
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101291"
FT   DOMAIN          182..264
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   301 AA;  31915 MW;  6FF3522ABEB1A9F7 CRC64;
     MLLDTASLYF RAYFGVPDSV KAPDGTPVNA VRGLLDFIDR LVKDHRPEHL VACMDADWRP
     HWRVELIPSY KAHRVAEERP AGPDAEEVPD TLSPQVPVIE AVLDALGIAR VGVAGYEADD
     VIGTYTARAT GPVDIVTGDR DLYQLVDDAR GVRVLYPVKG VGTLNLVDEA ALREKYGVDG
     AGYADLALLR GDPSDGLPGV PGIGEKTAAK LLAEFGDLAG IQAAVDDPKA RLTPTQRKRL
     TEAGPYLAVA PKVVRVAADV PLPDTGTALP HGPRDAAALE ALAARWGLGG SLQRLLTTLT
     A