ID   EX53_UREPA              Reviewed;         289 AA.
AC   Q9PQ75;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=5'-3' exonuclease;
DE            EC=3.1.11.-;
GN   Name=polA; OrderedLocusNames=UU414;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: 5'-3' exonuclease acting preferentially on double-stranded
CC       DNA. {ECO:0000250}.
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DR   EMBL; AF222894; AAF30825.1; -; Genomic_DNA.
DR   RefSeq; WP_006688635.1; NC_002162.1.
DR   AlphaFoldDB; Q9PQ75; -.
DR   SMR; Q9PQ75; -.
DR   STRING; 273119.UU414; -.
DR   EnsemblBacteria; AAF30825; AAF30825; UU414.
DR   GeneID; 29672547; -.
DR   KEGG; uur:UU414; -.
DR   eggNOG; COG0258; Bacteria.
DR   HOGENOM; CLU_004675_1_5_14; -.
DR   OMA; WRVDLIP; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646; PTHR42646; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..289
FT                   /note="5'-3' exonuclease"
FT                   /id="PRO_0000101289"
FT   DOMAIN          176..269
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   289 AA;  32944 MW;  26E747EF0FE5CEDF CRC64;
     MKKAIVIDGN SLIYRAFHAT YKQAEWAVEK QLMPTNAIKL VASMIFKILN QEQFTYGLIA
     MDASKQTFRA QEYAAYKATR KPMDAKLIVQ LPYLKKLFVA MGFRIISQPG IEADDFVGSF
     SNLMNKFDVD TTIYSSDRDM LQLINKNTKL KLLKTGTSVM QEINLTNFSL LNNGILPYQI
     IEYKGLVGDS SDNLIGVKGI GPKTAINLLL KYDNIENIYT NLEKIAPSVK NKLIEHKDMA
     FLSKKLAAIQ TDLLFDEKLE NFVLKPYNTQ ELDELFTSLK INNMQNYYK