EX7L_ACHLI
ID EX7L_ACHLI Reviewed; 446 AA.
AC A9NFG5;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=ACL_0476;
OS Acholeplasma laidlawii (strain PG-8A).
OC Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC Acholeplasma.
OX NCBI_TaxID=441768;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG-8A;
RX PubMed=21784942; DOI=10.1128/jb.05059-11;
RA Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A.,
RA Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D.,
RA Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A.,
RA Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I., Alexeev D.G.,
RA Ladygina V.G., Govorun V.M.;
RT "Complete genome and proteome of Acholeplasma laidlawii.";
RL J. Bacteriol. 193:4943-4953(2011).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000896; ABX81095.1; -; Genomic_DNA.
DR RefSeq; WP_012242426.1; NC_010163.1.
DR AlphaFoldDB; A9NFG5; -.
DR STRING; 441768.ACL_0476; -.
DR EnsemblBacteria; ABX81095; ABX81095; ACL_0476.
DR GeneID; 66293472; -.
DR KEGG; acl:ACL_0476; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_14; -.
DR OMA; RYMENAI; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000008558; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..446
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000200654"
SQ SEQUENCE 446 AA; 50804 MW; F5858B15101AA98F CRC64;
MNEQKYLSVS ALTEYIKVKL ENDNHLKRVF LKGEISNFTH HGSGHLYFSL KDEDAAISAM
MFKTYASTLS FKPKAGDKVL VEGYISLYKA RGTYSISIFS MTLDGIGELF LKYEQNRKMF
QELGYFDESL KKPIPKFPKI IAVITSETGA VIQDIKTTIS RRYLLAKIEL YPILVQGEGS
KDDIVKTLAR VNRESQADVI ILGRGGGSIE DLWSFNEAEV VVAIHQSKIP VITAIGHETD
TTLSDYVSDL RAPTPTAAAE LATPNMADLI KEIKDKVQLS QYYMNERIKN YTALILNLDE
RLELASPKSK LELEHKQIDN LTSKLTYFYK SKLTDNLNQV RLLSQRLTSP DEKIERYKER
IETLTSRINL LYKKQVDLKT YEYQSSLKQL QGLDPLRIMQ RGFSLTTKNQ KVITSIEQIN
TNDELDIQYK DGTAKVKVLS KEGKHI
