EX7L_BARBK
ID EX7L_BARBK Reviewed; 476 AA.
AC A1UTK7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN OrderedLocusNames=BARBAKC583_1034;
OS Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=360095;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35685 / NCTC 12138 / KC583;
RA Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S.,
RA Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R.,
RA Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J.,
RA Fraser-Ligget C., Seshadri R.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000524; ABM44707.1; -; Genomic_DNA.
DR RefSeq; WP_005767582.1; NC_008783.1.
DR AlphaFoldDB; A1UTK7; -.
DR SMR; A1UTK7; -.
DR STRING; 360095.BARBAKC583_1034; -.
DR PRIDE; A1UTK7; -.
DR EnsemblBacteria; ABM44707; ABM44707; BARBAKC583_1034.
DR KEGG; bbk:BARBAKC583_1034; -.
DR PATRIC; fig|360095.6.peg.1003; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_5; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000000643; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..476
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000079973"
SQ SEQUENCE 476 AA; 53314 MW; 9CE412A3AEE3D5B5 CRC64;
MADFFTEKPV ATNVAEFSVS EIANALKRVV EDKFGYVRIR GEISGYRGAH ASGHAYFALK
DDKARLEAVI WLSVMKKLSF PPEEGMEVIA VGKLTTYPGS SKYQIVIEAL EPTGVGALMT
LLENRKKKLA EEGLFDAANK KPLPYMPKII GVVTSPTGAV IRDIIHRIFD RFPLHILVWP
VRVQGETCGR EVASAVEGFN ALFLGGGIPK PDLIIVARGG GSLEDLWGFN DEAVVRAVYA
SAIPVISAVG HETDWTLIDY AADWRAPTPT GAAERAVPVK LDIEVHLASI NSRFRVGLAR
YFDFHQQKLR ALVRGLPTVD QLFALPRRGF DEISSRLQRA LCVSYDKKCF YFHALSLRFS
PRLLNTKKAQ YAIQEYTGRL HRAFLRNVEK QRAQVEMACR LLKSTSYQNI LERGFVLALG
KDHKPIKRLM QLPETGQISL RFFDGEIDVS THDRAVNRSL KNKRIKSQKD DQGLLF
