ID   EX7L_BEII9              Reviewed;         549 AA.
AC   B2IJK8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Bind_1238;
OS   Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB
OS   8712).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Beijerinckiaceae; Beijerinckia.
OX   NCBI_TaxID=395963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9039 / DSM 1715 / NCIMB 8712;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., LaButti K., Schmutz J., Larimer F.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., Dunfield P.F., Dedysh S.N.,
RA   Liesack W., Saw J.H., Alam M., Chen Y., Murrell J.C., Richardson P.;
RT   "Complete sequence of chromosome of Beijerinckia indica subsp. indica ATCC
RT   9039.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP001016; ACB94880.1; -; Genomic_DNA.
DR   RefSeq; WP_012384237.1; NC_010581.1.
DR   AlphaFoldDB; B2IJK8; -.
DR   SMR; B2IJK8; -.
DR   STRING; 395963.Bind_1238; -.
DR   PRIDE; B2IJK8; -.
DR   EnsemblBacteria; ACB94880; ACB94880; Bind_1238.
DR   KEGG; bid:Bind_1238; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000001695; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..549
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000205668"
FT   REGION          511..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  60338 MW;  AE394D2CA4F52C86 CRC64;
     MIGHLAAMLP PPSTNSPELT VSELSAALKR TLEDRFGIVR LRGEISNYRG PHSSGHAYFC
     LKDQNARIDA VIWKTTFMRL KVKPEEGLEV IATGKITTYA GKSSYQIVVE AIEPAGLGAL
     MALFEARRRQ LASEGLFDEE RKRALPFLPA VIGVITSPTG AVIRDILHRI TERFPRPVLL
     WPVRVQGETA AAEVSAAIEG FNALPVTGQG PLHRPDLLIV ARGGGSLEDL WGFNEENVVR
     AAAASSIPLI AAIGHETDWT LIDYAADLRA PTPTGAAEKA VPVRADLLTS LNDLQRRHAG
     AAYRLLERRR SDLRALARAL PQADSLLATP RQRLDRTATR LATACLRAQD QRGLVLGRLA
     HRLSRQAPHA SLARLGQKLE AFGRGLGRAC EIAQERRRQS LLHLGIRLTQ NFTQGIRVER
     ERVHGRRQKL ASLDNRLRQA MSLTLSQRQA RLANLAQLTR SLSYHAVLAR GFALVRDETG
     QPLRRAADII ENHVLTLEFS DGCRQAVAGA LVATDPPVDP KPTRKPVQKS SSPKPSSRKP
     KKSQQEDLF