ID   EX7L_BRADU              Reviewed;         545 AA.
AC   Q89DD2;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=blr7507;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; BA000040; BAC52772.1; -; Genomic_DNA.
DR   RefSeq; NP_774147.1; NC_004463.1.
DR   RefSeq; WP_011090239.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89DD2; -.
DR   SMR; Q89DD2; -.
DR   STRING; 224911.27355790; -.
DR   EnsemblBacteria; BAC52772; BAC52772; BAC52772.
DR   GeneID; 64027264; -.
DR   KEGG; bja:blr7507; -.
DR   PATRIC; fig|224911.44.peg.7609; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   InParanoid; Q89DD2; -.
DR   OMA; LVWPVKV; -.
DR   PhylomeDB; Q89DD2; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..545
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197829"
FT   REGION          499..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  59351 MW;  2748728003510E28 CRC64;
     MPNRLPMPPA EPLLNAPEFT VSELSQSLKR TVEDAFGHVR VRGEISGFRG AHSSGHCYFA
     LKDESAKIEA VIWKGVHGRM RFKPQEGLEV IATGKLTTYP GSSKYQIVIE ALEPAGIGAL
     MALMEERKKK LAAEGLFDEA RKQLLPWLPE VIGVVTSPTG AVIRDILHRL EDRFPRHVLV
     WPVKVQGEGS AEQVAAAIRG FNALPEGGKI PRPDVLIVAR GGGSLEDLWS FNEEIVVRAA
     AESMIPLISA VGHETDITLI DFVADKRAPT PTAAAEMAVP VRSDLFVEVA DLARRTRAYW
     QRAHESRRSE LRAAARALPA AGDLLAIPRQ RLDSAGAALP RGLKANTHAH FRRFTAAGAK
     LTLRVLHGQI AQADHRLTVC GERLGLSARS LLRQRRDRFA GLEVRLRASK LSNAQAQRNA
     IARQRERTHR LAERANRALV TLLQRLDARV EASGKLLSAL SYRGVLARGF ALVRDEAGHP
     LHSADSVGPG ARVEIEFADG RVGATTDADR PAPPAKRAQQ PKPAAQETKP APKRVGKPVD
     QGSLF