ID   EX7L_BRUA4              Reviewed;         527 AA.
AC   A6X3A0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Oant_2996;
OS   Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS   LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=21685287; DOI=10.1128/jb.05335-11;
RA   Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA   Ugalde R.A., Garcia E., Tolmasky M.E.;
RT   "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT   pathogen and symbiont of several eukaryotic hosts.";
RL   J. Bacteriol. 193:4274-4275(2011).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000759; ABS15704.1; -; Genomic_DNA.
DR   RefSeq; WP_011982723.1; NC_009668.1.
DR   AlphaFoldDB; A6X3A0; -.
DR   SMR; A6X3A0; -.
DR   STRING; 439375.Oant_2996; -.
DR   EnsemblBacteria; ABS15704; ABS15704; Oant_2996.
DR   KEGG; oan:Oant_2996; -.
DR   PATRIC; fig|439375.7.peg.3147; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   OrthoDB; 1371775at2; -.
DR   PhylomeDB; A6X3A0; -.
DR   Proteomes; UP000002301; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..527
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000048778"
FT   REGION          499..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..527
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   527 AA;  57887 MW;  E1D4F990E799BFEA CRC64;
     MGSDSSFTGA SSNVAEYSVS EISGALKRTV EDTFGHVRVR GEISGYRGPH SSGHAYFALK
     DDRARLEAVI WRGSMSRLRF RPEEGMEVIA TGKLTTYPGS SKYQIVIEQM EPAGAGALMA
     LLEERKRRLA TEGLFDPAVK QLLPFMPRVI GVVTSPTGAV IRDIIHRIAD RYPLHVIVWP
     VRVQGETSGP EVAAAVDGFN ALPDEGNIPR PDVLIVARGG GSLEDLWGFN DEIVVRAVAA
     SHIPVISAVG HETDWTLIDL AADIRAPTPT GAAEMAVPVK ADLLATLAGQ SARLSSAMSR
     FIDLKRQAHR SAARALPSAD QLLALPRRRF DEAAARLTRA LFVNTQKKRV HFDGHARQLS
     PRLLQRRFTE LQRDVSALGQ RLPRALEAFL RERRTAFIHR ANRLSAEPIL RRTKLTSVAI
     EQLDRRRDQA VRLLIERAKR RGQELERLMR TLSYESVLER GFAVVFDEEG KPVKQAGSVS
     AGDALSIRFR DGEVAVVAGD EDESEPAKLV QTKKVQSPGS GNQGSLF