ID   EX7L_CAUSK              Reviewed;         528 AA.
AC   B0SY33;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Caul_1226;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter; unclassified Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000927; ABZ70356.1; -; Genomic_DNA.
DR   RefSeq; WP_012285283.1; NC_010338.1.
DR   AlphaFoldDB; B0SY33; -.
DR   STRING; 366602.Caul_1226; -.
DR   PRIDE; B0SY33; -.
DR   EnsemblBacteria; ABZ70356; ABZ70356; Caul_1226.
DR   KEGG; cak:Caul_1226; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   OrthoDB; 1371775at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..528
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000079978"
FT   REGION          486..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  57101 MW;  75FDE393F4B54153 CRC64;
     MTDVVPDSNA PAYSVSELAF ALKRTLETSY AFVRLRGELS KVTHHGNGHV YLTIKDDKSA
     IDGVVWKGNV RGLGIRPEHG LEVIVTGKIT TYPAGSRYQI VIETMEAAGV GALLAQLERL
     KAKLNAEGLF APDRKRPLPS MPAVVGVITS PTGAVIRDIL HRIRDRWPCQ VLVWPCVVQG
     DAAAGQVSAA IRGFNALTPG GPVPRPDILI VARGGGSVED LWAFNDEGLA RTVAEGTIPL
     ISAVGHETDT TLIDFVSDRR APTPTAAAEM ATPVLAELRA LVSDYDRRLN NCGGRAVEER
     RTRLTSAARG LPRPADLLAL AQQRLDLAVR GLPRLDDLTA PAERRFKEAA ARLDTALQRN
     TDIHARDLLK VTARLSPDTL HRQRADAGRR VGDLGRRLDL AARRVPERVA QHARLPALQD
     RLNAVARRRL ERETDRLAGL EKLRQSLNPT RPLELGFALV HKADGGIARS ASELASGERV
     RLQFRQGDRD AVIDGESSGV LPPSAAPAPT RPTPRPKPAS SSDQGSLF