ID   EX7L_CERS1              Reviewed;         519 AA.
AC   A3PGZ4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN   OrderedLocusNames=Rsph17029_0494;
OS   Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=349101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17029 / ATH 2.4.9;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.,
RA   Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000577; ABN75610.1; -; Genomic_DNA.
DR   RefSeq; WP_011840393.1; NC_009049.1.
DR   AlphaFoldDB; A3PGZ4; -.
DR   SMR; A3PGZ4; -.
DR   EnsemblBacteria; ABN75610; ABN75610; Rsph17029_0494.
DR   GeneID; 57469187; -.
DR   KEGG; rsh:Rsph17029_0494; -.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..519
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000303815"
FT   REGION          500..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  56309 MW;  05859DFB9B17EE5A CRC64;
     MSDLFEDPAP SRNTPEFTVS ELSGAVKRVI EGEFGLVRVR GEIGRVSRPA SGHLYFDLKD
     DRAVMAAICW KGQAGRLSVR PEEGMEVVAT GRMTTFPGQS KYQIIVEDMA PAGAGALMAM
     LEKRRAALAA EGLFDAGRKR PLPFLPRVIG VVTSPSGAVI RDILHRLRDR FPSHVLIWPV
     AVQGEKCAPE VAAAIRGFNT LPEGGPIPRP DLLIVARGGG SLEDLWGFNE EIVVRAAAES
     RIPLISAVGH ETDTTLIDHA ADRRAPTPTA AAEMAVPVRL ELLAGLDGQG ARLSRCAAET
     IRRRDQRLRD LARALPRLES LVAGPSQRFD LWSGRLSGAL GQSVAARRAR LEPLGAHLRP
     RLLADLVARQ KDRLGDRTRS LETCLGRRAE RARDRFDALS ARLAPAFARL IAETERASRR
     DAATLGTLAA RLDAAPEARL ARLSDRLEAL DRLRQTLGYR ETLKRGYAVV RADGAVLTTK
     AEAGAAAMLE IEFQDGRLSV GRGKTRKPKE EPPAQGSLL