ID   EX7L_CERS4              Reviewed;         519 AA.
AC   Q3J5E0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RHOS4_04260;
GN   ORFNames=RSP_1845;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000143; ABA77994.1; -; Genomic_DNA.
DR   RefSeq; WP_011337024.1; NZ_CP030271.1.
DR   RefSeq; YP_351895.1; NC_007493.2.
DR   AlphaFoldDB; Q3J5E0; -.
DR   SMR; Q3J5E0; -.
DR   STRING; 272943.RSP_1845; -.
DR   EnsemblBacteria; ABA77994; ABA77994; RSP_1845.
DR   KEGG; rsp:RSP_1845; -.
DR   PATRIC; fig|272943.9.peg.732; -.
DR   eggNOG; COG1570; Bacteria.
DR   OMA; LVWPVKV; -.
DR   PhylomeDB; Q3J5E0; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..519
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000303814"
FT   REGION          500..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  56330 MW;  929317CE39872720 CRC64;
     MSDLFEDPAP SRNTPEFTVS ELSGAVKRVI EGEFGLVRVR GEIGRVSRPA SGHLYFDLKD
     DRAVMAAICW KGQAGRLSVR PEEGMEVVAT GRMTTFPGQS KYQIIVEDMA PAGAGALMAM
     LEKRRAALAA EGLFDAARKH PLPFLPRVIG VVTSPSGAVI RDILHRLRDR FPSHVLIWPV
     AVQGEKCAPE VAAAIRGFNA LPEGGPIPRP DLLIVARGGG SLEDLWGFNE EIVVRAAAES
     RIPLISAVGH ETDTTLIDHA ADRRAPTPTA AAEMAVPVRL ELLAGLDGQV ARLSRCAAET
     IRRRDQRLRD LARALPRLES LVAGPSQRFD LWSGRLSGAL GQSVAARRAR LEPLGAHLRP
     RLLADLVARQ KDRLGDRTRS LETCLGRRAE RARDRFDALS ARLAPAFARL IAETERATRR
     DAATLGTLAA RLDAAPEARL ARLSDRLEAL DRLRQTLGYR ETLKRGYAVV RADGAVLTTK
     AEAGAAAMLE IEFQDGRLSV GRGKTRKPKE EPPAQGSLL