ID   EX7L_CERS5              Reviewed;         519 AA.
AC   A4WQ76;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN   OrderedLocusNames=Rsph17025_0634;
OS   Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=349102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17025 / ATH 2.4.3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M.,
RA   Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000661; ABP69540.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4WQ76; -.
DR   SMR; A4WQ76; -.
DR   STRING; 349102.Rsph17025_0634; -.
DR   EnsemblBacteria; ABP69540; ABP69540; Rsph17025_0634.
DR   KEGG; rsq:Rsph17025_0634; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   OrthoDB; 1371775at2; -.
DR   BioCyc; RSPH349102:G1G8M-655-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..519
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000048779"
SQ   SEQUENCE   519 AA;  56325 MW;  F5E049FE97BA37E6 CRC64;
     MSDLFEDPAP ARNTPEYTVS ELSGAVKRVI EGEFGLVRVR GEIGRVSRPA SGHLYFDLKD
     DRAVIAAICW KGQAGRLSVR PEEGMEVVAT GRMTTFPGQS KYQIIVEDMA PAGAGALMAM
     LEKRRAALAA EGLFDAARKR PLPFLPRVIG VVTSPSGAVI RDILHRLRDR FPSHVLIWPV
     AVQGEKCAPE VAAAIRGFNA LPDGGPIPRP DLLIVARGGG SLEDLWGFNE EIVVRAAAES
     RIPLISAVGH ETDTTLIDHA ADRRAPTPTA AAEMAVPVRL DLLAGLDGQG ARLSRCAAET
     IRRRDQRLRD LSRALPRLDS LVAGPSQRFD LWSARLSGAL GQSVAARRAR LEPLGAHLRP
     RLLADLVARQ KDRLADRGRG LETCLGRRSE RARDRFEALS GRLAPAFARL VAESERTNRR
     DAAALGALAA RLEAAPEARL LRLADRLEAL DRLRQTLGYR ETLRRGYAVV RADGEVVTTK
     TAAERAASLE IEFQDGRLTL GARKPRKGKA EPPAQGSLL