ID   EX7L_CHLAB              Reviewed;         555 AA.
AC   Q5L6H1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=CAB304;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR848038; CAH63754.1; -; Genomic_DNA.
DR   RefSeq; WP_011096971.1; NC_004552.2.
DR   AlphaFoldDB; Q5L6H1; -.
DR   EnsemblBacteria; CAH63754; CAH63754; CAB304.
DR   KEGG; cab:CAB304; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_5_0_0; -.
DR   OMA; KIACTIW; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..555
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000273651"
SQ   SEQUENCE   555 AA;  63857 MW;  26EE66D5AA83B5B8 CRC64;
     MATSSPPQAV TTLTESIKNL LESNFCHIVV KGELSNVSLQ PSGHLYFGIK DSKSFLNGAF
     FHFKSKYFDR RPKDGDSVII HGKLTVYAPR GQYQIVAHAL VYAGEGDLLQ KFEETKKRLA
     AEGYFSIEKK QPLPRIPKCI GVITSPTGAV IQDILRILSR RCYQYKVLIY PVTVQGATAA
     KEISQAIEVM NRDKLVDVLV IARGGGSIED LWAFNEEIIV KAIDASTIPI ISAVGHETDY
     TLCDFAADVR APTPSAAGEI VCQSSQEQIQ IFKSHLRYLN AHAQQLLAGK AKQIQQWKRY
     LDHVDFFRPP HQSLDYLRVS IERSIQTTLS QSKQRYRQYT RWLQSDILQR MTYRLQDLWK
     MINLAFQNRL LALKHHCVHI KKNLVIHNTQ QYRQRFDPCR DQIHRALSQR LGYFQQSLAH
     KQTLLKHFTT KINQLFIKET SALNLLKKRL NKAFVYTVCE RREHFLYAKE NLFLSLNHLV
     ERHRAKYHTV SQQLISLNPK NVLKRGYAML FDFNENSAII SAKSLHKHSC VRVRLQDGEA
     TLTVTDVQNF ETQEF