ID   EX7L_CHLCV              Reviewed;         555 AA.
AC   Q823U8;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=CCA_00307;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AE015925; AAP05056.1; -; Genomic_DNA.
DR   RefSeq; WP_011006274.1; NC_003361.3.
DR   AlphaFoldDB; Q823U8; -.
DR   STRING; 227941.CCA_00307; -.
DR   EnsemblBacteria; AAP05056; AAP05056; CCA_00307.
DR   KEGG; cca:CCA_00307; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_5_0_0; -.
DR   OMA; KIACTIW; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..555
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197834"
SQ   SEQUENCE   555 AA;  63967 MW;  6BCC1BD5C17A8DF7 CRC64;
     MTTSSPPQAV TTLTESIKNL LESNFCHIVV KGELSNVSLQ PSGHLYFGIK DNRSFLNGAF
     FHFKSKYFDR RPKDGDSVVI HGKLTVYAPR GQYQIIAHAL VYAGEGDLLQ KFEETKKRLA
     AEGYFAIEKK QALPTIPKSI GVITSPTGAV IQDILRVLSR RCYQYKLLIY PVTVQGATAA
     KEISRAIEEM NKENLADVLI LARGGGSIED LWAFNEEIIV KAIAASSIPI ISAVGHETDY
     TLCDFAADVR APTPSAAAEI VCQSSEQQIQ VLKSYLRYLN AHAQQLLSGK TKQIQQWKRY
     LDHVDFFRPA HQSLDYLCLS IERSIKIKLS QYKQRYMQYA RWLQSDVLQR MTYRLYDLWK
     MIVQAFHNRL IAAKHLCIHQ KKNLTFLNTQ QFIQKLDLWK QQTRRALRQR LGYCSQSLTH
     QQTSLKHFIT KLNQQFTKEN HALSLLQKRL TRTFANRVDE HRESYMRSRE NLIFSLHHLV
     KRNREKYSQV SKQLTLLNPK NVFKRGYAML FDFNENFAII SAKSLHKHSC VRVRLQDGEA
     TLTVTDIQNF ETQES