EX7L_CHLPN
ID EX7L_CHLPN Reviewed; 554 AA.
AC Q9Z6J7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN OrderedLocusNames=CPn_1062, CP_0787, CpB1105;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; AE001363; AAD19199.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38586.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA99269.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP99033.1; -; Genomic_DNA.
DR PIR; C72002; C72002.
DR PIR; C86623; C86623.
DR RefSeq; NP_225256.1; NC_000922.1.
DR RefSeq; WP_010883695.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z6J7; -.
DR STRING; 115711.CP_0787; -.
DR PRIDE; Q9Z6J7; -.
DR EnsemblBacteria; AAD19199; AAD19199; CPn_1062.
DR EnsemblBacteria; AAF38586; AAF38586; CP_0787.
DR GeneID; 45051121; -.
DR KEGG; cpa:CP_0787; -.
DR KEGG; cpj:xseA; -.
DR KEGG; cpn:CPn_1062; -.
DR KEGG; cpt:CpB1105; -.
DR PATRIC; fig|115713.3.peg.1162; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_5_0_0; -.
DR OMA; KIACTIW; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 2.
DR Pfam; PF02601; Exonuc_VII_L; 2.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..554
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000197836"
SQ SEQUENCE 554 AA; 62911 MW; 466902ABAF19F052 CRC64;
MSSPPQAVAS LTERIKTLLE SNFCQIIVKG ELSNVSLQPS GHLYFGIKDS QAFLNGAFFH
FKSKYYDRKP KDGDAVIIHG KLAVYAPRGQ YQIVAHALVY AGEGDLLQKF EETKRRLTAE
GYFATEKKKP LPFAPQCIGV ITSPTGAVIQ DILRVLSRRA RNYKILVYPV TVQGNSAAHE
ISKAIEVMNA ENLADVLIIA RGGGSIEDLW AFNEEILVKA IHASTIPIVS AVGHETDYTL
CDFASDVRAP TPSAAAEIVC KSSEEQVQVF EGYLRHLLSH SRQLLTSKKQ QLLPWRRFLD
RAEFYTTAQQ QLDSIEIAIQ KGVQGKIHES KQRYDNISRW LQGDLVSRMT CRLQSLKKML
SQALSHKALS LQVRCHQLKK SLTYPRQIQQ ASQKLSPWRQ QLDTLISRRL HYQKEEYFHK
HTRLKHAHNV LEQQLRSHVQ KLELLGRRLS RGCELNLQNQ KIAYANVKET LATILERRYE
NSVARYSALK EQLHSLNPKN VLKRGYAMLF DFNENSAMIS VDSLQENARV RIQLQDGEAI
LTVTNIEICK LIKG
