EX7L_CITBB
ID EX7L_CITBB Reviewed; 458 AA.
AC B5EI10;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Gbem_1255;
OS Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 /
OS Bem) (Geobacter bemidjiensis).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Citrifermentans.
OX NCBI_TaxID=404380;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Lovley D., Richardson P.;
RT "Complete sequence of Geobacter bemidjiensis BEM.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP001124; ACH38274.1; -; Genomic_DNA.
DR RefSeq; WP_012529686.1; NC_011146.1.
DR AlphaFoldDB; B5EI10; -.
DR SMR; B5EI10; -.
DR STRING; 404380.Gbem_1255; -.
DR PRIDE; B5EI10; -.
DR EnsemblBacteria; ACH38274; ACH38274; Gbem_1255.
DR KEGG; gbm:Gbem_1255; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_7; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000008825; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..458
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000122064"
SQ SEQUENCE 458 AA; 50286 MW; 450663AC0E598599 CRC64;
MQLFKERRVL TVSALTALVR GLLEENFEQV WVEGEISNLA CPQSGHCYFT LKDVGAQIRC
VMFRGAFRSL KFTPRDGMRI LTRGRLTLFE PRGEYQLVAD YLEPQGIGGL QMAFIQLKEK
LAKEGLFSEL HKREIPKLPR RIGVVTSPTG AAIRDILTVL NRRFTNVELL ISPVRVQGDG
AAREIADAID DLNRVGNLDV MIVGRGGGSL EDLWAFNEEV VARAIHRSKV PVISAVGHEI
DFTIADFVAD LRAATPSAAA EIVVASKKEL TAEVEALTHR LHVSQQRRLE RSRALVTALS
RAITDPSRFL GHLAQRVDSL DARLTREAGL ILDDASERIV TLTARLSRQT PALTLKRWEE
RLATLSLRLD HAMTRRLAVA AESIGLATGT LNAVSPLATL SRGYSITRKL PARSVVTSSR
QLAPGDRVEV SFAAGSALCT VEQAHKDSDS LTAPPRSV
