EX7L_EDWI9
ID EX7L_EDWI9 Reviewed; 460 AA.
AC C5BER7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=NT01EI_3155;
OS Edwardsiella ictaluri (strain 93-146).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=634503;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146;
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP001600; ACR70305.1; -; Genomic_DNA.
DR RefSeq; WP_015872393.1; NC_012779.2.
DR AlphaFoldDB; C5BER7; -.
DR STRING; 67780.B6E78_07440; -.
DR EnsemblBacteria; ACR70305; ACR70305; NT01EI_3155.
DR GeneID; 7958673; -.
DR KEGG; eic:NT01EI_3155; -.
DR PATRIC; fig|634503.3.peg.2816; -.
DR HOGENOM; CLU_023625_3_1_6; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000001485; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..460
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000205672"
SQ SEQUENCE 460 AA; 51900 MW; 447FB6CBD135D25F CRC64;
MTQPVTPTIF TVSRLNQTVR QLLELEMGQI WLSAEISNLS QPASGHWYFT LKDDKAQVRC
AMFRNSNRRV TFRPQNGQQV LVRASITLYE SRGDYQLIAE SMQPAGDGLL QQQFEALKQR
LQAEGLFDVG HKQPLPSPAR CVGVITSTSG AALHDVLHVL RRRDPALPVV IYPSAVQGGE
APGQLVRAIA LANLRAECDV LIVGRGGGSL EDLWSFNDER VARAIFASHI PIVSAVGHET
DVSIADFVAD LRAPTPSAAA EVVSRNRDEL LRRLLSQRQR LDMALDYTLA RRRQRLQQLR
HRLEQQHPQL RLARQQARLL SLHRRLEEAI DTQLRLAERR WRLGGERLQQ RSPAHALRQQ
QYHLQQLSHR LESQLQRSVA ARRERFGALC SRLEGMSPLA TLARGFSVTQ RDDGQLLRHR
EQVAPGDTLR TRLEDGWVES QVTATRPLTA RRPRGTKGSA
