EX7L_GEOMG
ID EX7L_GEOMG Reviewed; 453 AA.
AC Q39UJ7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Gmet_1848;
OS Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=269799;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53774 / DSM 7210 / GS-15;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Geobacter metallireducens GS-15.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000148; ABB32077.1; -; Genomic_DNA.
DR RefSeq; WP_004511998.1; NC_007517.1.
DR AlphaFoldDB; Q39UJ7; -.
DR STRING; 269799.Gmet_1848; -.
DR EnsemblBacteria; ABB32077; ABB32077; Gmet_1848.
DR KEGG; gme:Gmet_1848; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_7; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000007073; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..453
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000048773"
SQ SEQUENCE 453 AA; 50756 MW; 0B92285798613B22 CRC64;
MELFPEKRIL TVSQLTSLIR GVLEENFEHV WVEGEVSNLA MPASGHLYFT LKDAGAQIRC
VMFRASARAL KFRPRDGMGL IVRGRITVYE QRGDYQFLVE YLEPRGVGAL QLAFIQLKEK
LAKEGLFAEE HKRPIPSLPQ RIGVVTSATG AAIHDILNVL NRRFANVEVL IRPVKVQGEG
AADEIAEAII DFNRYGAVDV MIVGRGGGSL EDLWAFNEEK VARAVHRSRI PIISAVGHEI
DFTIADFVAD LRAPTPSAAA ELVVKSKEEL ASKVEFLRHR LIQTLRRILA DAGGELESLS
RALRDPTVLL GHLSQRLDDI FVRLERAIAG DLKDRGRMLE ALKNHLRLRN PALKVERARE
RVIALSDKSE IALLRHVDRY REAAAVHSAR LETLSPLGTL ARGYSVALKL PERVPVKTFR
QLALKDRLEL LFHHGRAWCR VESLDEDASC SHE
