EX7L_HELPJ
ID EX7L_HELPJ Reviewed; 420 AA.
AC Q9ZMH7;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=jhp_0243;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; AE001439; AAD05833.1; -; Genomic_DNA.
DR PIR; E71955; E71955.
DR RefSeq; WP_000558308.1; NZ_CP011330.1.
DR AlphaFoldDB; Q9ZMH7; -.
DR SMR; Q9ZMH7; -.
DR STRING; 85963.jhp_0243; -.
DR EnsemblBacteria; AAD05833; AAD05833; jhp_0243.
DR KEGG; hpj:jhp_0243; -.
DR PATRIC; fig|85963.30.peg.771; -.
DR eggNOG; COG1570; Bacteria.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..420
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000197851"
SQ SEQUENCE 420 AA; 47030 MW; 4B8DE16C3AF7C989 CRC64;
MHVLSVSEIN AQIKALLEAT FLQVRVQGEV SNLTIHKVSG HAYFSLKDSQ SVIRCVLFKG
NANRLKFALK EGQEMVVFGG ISVYAPRGDY QINCFEIEPK EIGSLTLALE QLKEKLRLKG
YFDEANKLPK PNFPKRVAVI TSQNSAAWAD MKKIASKRWP MCELVCINTL MQGEGCVQSV
VESIAYADSF YDTKNAFDAI VVARGGGSME DLYSFNDEKI ADALYLAKTF SMSAIGHESD
FLLSDSVADL RASTPSNAME ILLPSSDEWL QRLDGFNVKL HRSFKTLLHQ KKAHLEHLAA
SLKRLSFENK HHLNALKLEK LTIALDNKTL EFLRLKKTLL EKISTQLSTS PFLQTKTERL
NRLENALKLA YANLKLPQFG ALVSKNHQAI ELEALKRGDK IELSNEKARA SAEILSVDRV
