EX7L_LACH4
ID EX7L_LACH4 Reviewed; 447 AA.
AC A8YVW9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=lhv_1414;
OS Lactobacillus helveticus (strain DPC 4571).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=405566;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DPC 4571;
RX PubMed=17993529; DOI=10.1128/jb.01295-07;
RA Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA Beresford T., Ross R.P.;
RT "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT selective gene loss and IS element expansion.";
RL J. Bacteriol. 190:727-735(2008).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000517; ABX27399.1; -; Genomic_DNA.
DR RefSeq; WP_012212032.1; NC_010080.1.
DR AlphaFoldDB; A8YVW9; -.
DR SMR; A8YVW9; -.
DR STRING; 405566.lhv_1414; -.
DR EnsemblBacteria; ABX27399; ABX27399; lhv_1414.
DR KEGG; lhe:lhv_1414; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000000790; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..447
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000072161"
SQ SEQUENCE 447 AA; 51124 MW; 65472513F980FBDD CRC64;
MTDNKYLTVT DLNYYITQKF KNDPYLHKVF LQGELSNFRY RRNSHQYFSL KDEKSKINVV
MFRSYFDKVK FKPEEGMKVY VVGYVSVYGP QGSYQFYAEN MEPAGLGALY EQLKQLQAKL
AKEGLFNPEH KRKLPRFPDK IAVVTSASGA VIHDIMVTAN RRFPHAEIDL FPAQVQGDTA
ADSLVKAMRQ IAAQGDEYDV MIIGRGGGSL EDLWSFNEEE VVRQVYAMPM PVISSVGHET
DTTLCDLVAD ARAATPTAAA EYATPNLADE LAGIHQLQSR LIAGMQNNIN QKRDRLNRIK
NSVIMREPTR LYDQQIQQVD LLKQRLQNSI QNKVNNSLQN YRLLKQRLLS VSPDKQIAGM
EQQEKFLAKQ LNDNMKHYLK NKRSDFSKIV QQLDDYSPLK TLERGFVYTT NEEGETVSSV
DQIKKDDHLN LHFKDGEVTA TVTEVKK
