EX7L_LACJO
ID EX7L_LACJO Reviewed; 456 AA.
AC Q74IM1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=LJ_1549;
OS Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=257314;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNCM I-1225 / La1 / NCC 533;
RX PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT johnsonii NCC 533.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; AE017198; AAS09317.1; -; Genomic_DNA.
DR RefSeq; WP_011162268.1; NC_005362.1.
DR AlphaFoldDB; Q74IM1; -.
DR SMR; Q74IM1; -.
DR STRING; 257314.LJ_1549; -.
DR EnsemblBacteria; AAS09317; AAS09317; LJ_1549.
DR KEGG; ljo:LJ_1549; -.
DR PATRIC; fig|257314.6.peg.1366; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000000581; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..456
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000273664"
SQ SEQUENCE 456 AA; 52270 MW; F463F160AA48E2EF CRC64;
MVDNKVYLSV SDLNFYISQK FKNDPYLHKV FLQGELSNFR FRMNSHQYFS LKDEKSKINV
VMFRSFFEKL KFKPEEGMKV YVSGYVDVYG PQGSYQFYAQ TMEPAGLGAL YEQLRQLQEK
LAKEGLFNEE HKKKIPLFPD RIAVVTSASG AVIHDIMVTA NRRFPHAEID LYPAKVQGDE
AADTIVAALQ QIQAQGDKYD VVIIGRGGGS LEDLWPFNEE KVVRQIYAMQ MPVISSVGHE
TDTTLADLVA DARAATPTAA AEYATPNLVD VLTQIVQLRA RLYAAVQANI HTKHQILDRL
KNAPVLQEPT RIYDQQIQQV DMLIHRLNQA MDNRLQHDGS TLRLLQERLK ALSPSRKLEQ
LERERNFVVS NLFSTMNNYL KDQRNRLNRA MQQLDDISPL KTISRGYVYT TDQKGNIVTS
VDQLKIDEKL KLHFKDGQVQ VNVENIRREK NGNQEK
