EX7L_LACLA
ID EX7L_LACLA Reviewed; 417 AA.
AC Q9CH84;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=LL0854;
GN ORFNames=L0254;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; AE005176; AAK04952.1; -; Genomic_DNA.
DR PIR; F86731; F86731.
DR RefSeq; NP_267010.1; NC_002662.1.
DR RefSeq; WP_010905593.1; NC_002662.1.
DR AlphaFoldDB; Q9CH84; -.
DR STRING; 272623.L0254; -.
DR PaxDb; Q9CH84; -.
DR EnsemblBacteria; AAK04952; AAK04952; L0254.
DR KEGG; lla:L0254; -.
DR PATRIC; fig|272623.7.peg.915; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..417
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000197852"
SQ SEQUENCE 417 AA; 47122 MW; 322C1248B3A4145A CRC64;
MTEYLSVSTL TKYLKAKFDR DRYLERVYLT GEISNFRRRP NHQYFALKDE GAVIQATMWA
GQFRKLDFEL EEGMKVLAVG RISIYPPSGS YSINIESLVP DGVGALAVKF EQLKKKLTAE
GLFEQRWKQT LPQFSKKIAV VTSPSGAVIR DIITTVQRRF PMSQIVLYPT KVQGQGSAEE
IAGNIRRANQ RGDFDVMIIG RGGGSIEDLW GFNEEIVVRA IFESRIPIIS SVGHETDVTL
ADFVADSRAA TPTAAAELAT PNTKVDLINW ANEQEKRLFN RLTHVIKIRR ERVDKLSQSV
VFRQPERLYD GHLQKLDRLC ERLSVLTENK VANMKHRYEL SAGKLIPTYG KIVEAKKNKT
EQLYQSLLLL DISKIKARGF SLVTDEKGKI IKSVSDVKKG QTLDVELTDG KVIVEVK
