EX7L_LATSS
ID EX7L_LATSS Reviewed; 449 AA.
AC Q38XU8;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=LCA_0677;
OS Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS subsp. sakei).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Latilactobacillus.
OX NCBI_TaxID=314315;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23K;
RX PubMed=16273110; DOI=10.1038/nbt1160;
RA Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA Zagorec M.;
RT "The complete genome sequence of the meat-borne lactic acid bacterium
RT Lactobacillus sakei 23K.";
RL Nat. Biotechnol. 23:1527-1533(2005).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CR936503; CAI54981.1; -; Genomic_DNA.
DR RefSeq; WP_011374386.1; NC_007576.1.
DR AlphaFoldDB; Q38XU8; -.
DR STRING; 314315.LCA_0677; -.
DR EnsemblBacteria; CAI54981; CAI54981; LCA_0677.
DR KEGG; lsa:LCA_0677; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR BioCyc; LSAK314315:LCA_RS03425-MON; -.
DR Proteomes; UP000002707; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..449
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000273665"
SQ SEQUENCE 449 AA; 50698 MW; 47FB7AD481C76DDB CRC64;
MVKPTDYLTV TALTQYLKAK FERDPYLDRV YLTGEISNFR LRPNAHQYFS LKDNKAKISA
IMFKSAFEKV KFTPEEGMKV LIVGRISLYE ASGNYQIYVE RMEPDGLGAL YQAYEQLKAK
LATEGLFDAP KQPLVRFPKR IAVITSPSGA VIRDIITTTQ RRYPIAQLVL FPAVVQGDGA
ADVLVERLKQ VNEHGDFDTI IIGRGGGSIE DLWPFNEERV ARAIVASQIP VISSVGHETD
TTIADLVADV RAATPTAAAE LATPVLTDEI LKLQQQRLRL YQAFSKTVAL NKKQLDHLQN
SYVLKQPKRL YDGYLQNVDQ LQRRLLTAQQ QLLKDRRQQV QLLQQRLMAQ SPLMAVRQAQ
KDVTEQQRRL NQAMNRLMAD RRQKAAQVIA ALDLVSPLKI LGRGFAYVTD DQQQMLKKVA
DFKTQQPIEL HVQDGLVTAE VVATHKGEE
