ID   EX7L_LEPIN              Reviewed;         422 AA.
AC   Q8F3P5;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=LA_2356;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AE010300; AAN49555.1; -; Genomic_DNA.
DR   RefSeq; NP_712537.1; NC_004342.2.
DR   RefSeq; WP_000390226.1; NC_004342.2.
DR   AlphaFoldDB; Q8F3P5; -.
DR   SMR; Q8F3P5; -.
DR   STRING; 189518.LA_2356; -.
DR   EnsemblBacteria; AAN49555; AAN49555; LA_2356.
DR   KEGG; lil:LA_2356; -.
DR   PATRIC; fig|189518.3.peg.2339; -.
DR   HOGENOM; CLU_023625_3_1_12; -.
DR   InParanoid; Q8F3P5; -.
DR   OMA; WPAVRFE; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..422
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197855"
SQ   SEQUENCE   422 AA;  47093 MW;  ACE6D57F23379A8E CRC64;
     MEDSKPLSVS EVTRIIKNLI SGSKDLKNIW VRGEISNYSK ASSGHIYFSL KDAGSLIRCT
     FFNYSNKNYS GKPLSDGKEI QVYGTITLYE AGGSYNLNVT RVEELGQGDI LLQIEKLKQK
     LAVEGIFDPE KKRRIPSFPK TLGIATSPTG AAIEDIIKIS RSRFPGINIL IAPCIVQGED
     APDSIVAAIE ELNHPNWKVD VIIAGRGGGS FEDLMAFNDE KVVRAYANSR VPIISAVGHQ
     TDVLLSDFAA DHFTPTPTAA AEYAIPKEED VLQFLSQLEG RIKSSLVTKI SSNRDRLRLL
     SGKFIFKEPM QLLNQRSQRV DEIGIRLQKA LSNKLNLARV RLERYQNLTS RIQNILFHKK
     QKAEFWTSKV EDLSPAATMK RGYSILRNEN GKIIRSPEET KPEEELQVLL SGGTMQVIRK
     GK