ID   EX7L_LIMRD              Reviewed;         445 AA.
AC   A5VKR6;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Lreu_1183;
OS   Limosilactobacillus reuteri (strain DSM 20016) (Lactobacillus reuteri).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=557436;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20016;
RX   PubMed=21379339; DOI=10.1371/journal.pgen.1001314;
RA   Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M.,
RA   Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M.,
RA   Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L., Ivanova N.,
RA   Kyrpides N.C., Walter J.;
RT   "The evolution of host specialization in the vertebrate gut symbiont
RT   Lactobacillus reuteri.";
RL   PLoS Genet. 7:E1001314-E1001314(2011).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000705; ABQ83440.1; -; Genomic_DNA.
DR   RefSeq; WP_003668406.1; NZ_AZDD01000001.1.
DR   AlphaFoldDB; A5VKR6; -.
DR   STRING; 557436.Lreu_1183; -.
DR   EnsemblBacteria; ABQ83440; ABQ83440; Lreu_1183.
DR   GeneID; 66471254; -.
DR   KEGG; lre:Lreu_1183; -.
DR   PATRIC; fig|557436.17.peg.49; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_2_0_9; -.
DR   OMA; WPAVRFE; -.
DR   Proteomes; UP000001991; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..445
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_1000122070"
SQ   SEQUENCE   445 AA;  50628 MW;  D34EDE00A7A8859E CRC64;
     MDRSQYLTVS ELTKYLKMKF DRDPYLHTVY LTGELSNFRL RQKHQYFSLK DDNAVIDAVM
     FEHQFRKIKF TPEQGMKVCV VGHVSLYEKS GRYQIYIDRM EPDGLGSLYL AFEQLKKKLS
     AEGLFNLPKK QIPMFPKRIA VVTSIDGAVI RDINTTVRRR YPIAQVVLYP TVVQGDKAAA
     DIARQINRAN DRGDFDTLII GRGGGSMEDL WPFNEEVVAR AIANSKIPVI SSVGHETDTT
     IADLVADQRA ATPTAAAELA TPVKLNDALM TLKDDQNRLL NTMRTKINFD RQQLNKQLQS
     YIFQQPTRLY ENYAQKVDQL TQQLGQAAQN KMQELQMNVE RLSGRLTAAS PLHRVQQQEQ
     LVDQLKKQLV TASLASQNEK KQQVTTLIKQ LDSLSPLKIM SRGYTYVTSD EKVVNHASQL
     TVGQNVHLHF DDGEVQAEIK KVKEH