ID   EX7L_LISMO              Reviewed;         450 AA.
AC   Q8Y7C4;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=lmo1361;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AL591978; CAC99439.1; -; Genomic_DNA.
DR   PIR; AI1244; AI1244.
DR   RefSeq; NP_464886.1; NC_003210.1.
DR   RefSeq; WP_010990104.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y7C4; -.
DR   STRING; 169963.lmo1361; -.
DR   PaxDb; Q8Y7C4; -.
DR   DNASU; 987878; -.
DR   EnsemblBacteria; CAC99439; CAC99439; CAC99439.
DR   GeneID; 987878; -.
DR   KEGG; lmo:lmo1361; -.
DR   PATRIC; fig|169963.11.peg.1398; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_9; -.
DR   OMA; WPAVRFE; -.
DR   PhylomeDB; Q8Y7C4; -.
DR   BioCyc; LMON169963:LMO1361-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..450
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197858"
SQ   SEQUENCE   450 AA;  51181 MW;  38F8029A4042A720 CRC64;
     MEQDKYLTVA AITKYIEKKF EVDPYMKQVF VRGEISNLKQ PASGHLYFTV KDEFAMLRSV
     MFHKAVQKIG FVPEDGMNVL VTGRIGVFTK AGRYQFYAEH MEPDGVGALY IQLEQLKAQL
     EKEGLFAETH KKVLPSFPSK VAVVTSKTGA AVRDILTTIH RRMPSVEVIV YPTIVQGEKA
     AQKIVENIGK INQRNDIDVM IIGRGGGSLE ELWAFNEEPV VRAVYDSDVP VISAVGHETD
     FALSDFSADV RAATPTAAAE LAVPDYRDLE ERLAERKYRL LAVTRQALER KERSLEQLKQ
     HLILNGPKHQ LEQQMERTDY FSERLNNAFS KQIFVKQTAF DRLNDRLHYY HPNKEIELQK
     EQMTLHLQAL DKAMKQLLKD KQQSFFRQVD ALEHLSPLSL LKRGFGVTYK ENTLVKSVQE
     LEVGDNIQVK MQGGHIDALI TAKEEDISGN