ID   EX7L_NEIMA              Reviewed;         451 AA.
AC   Q9JTY8; A1ISG4;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=NMA1575;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AL157959; CAM08720.1; -; Genomic_DNA.
DR   PIR; B81850; B81850.
DR   RefSeq; WP_002229594.1; NC_003116.1.
DR   AlphaFoldDB; Q9JTY8; -.
DR   EnsemblBacteria; CAM08720; CAM08720; NMA1575.
DR   GeneID; 61281550; -.
DR   KEGG; nma:NMA1575; -.
DR   HOGENOM; CLU_023625_3_1_4; -.
DR   OMA; WPAVRFE; -.
DR   BioCyc; NMEN122587:NMA_RS07865-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..451
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197862"
SQ   SEQUENCE   451 AA;  49849 MW;  F1A55EBD96139FAB CRC64;
     MSDFFHSDVL SVSELNAFAK SLLENHLAGL WIAGEVSNLT RAASGHYYFS LKDSRAQVRC
     AMFKGAAARL AKPLKEGDHI EVSGKISIYE ARGEFQITVN EVRLKGLGQL YEAYERLKAQ
     LQAEGAFAAE RKKPLPTRPQ CIGIVTSLAA AALRDVVTTL KRRAPEIPVI VYPTPVQGAG
     SELQIAQAIK TASQRAECDV LIVCRGGGSI EDLWAFNEEP VVRAIEACTV PVVSGVGHET
     DFTLADFVAD VRAPTPTGAA ELVSPNRQES LHRLAQAQGR LKTVLEQRYF DASQKLDWLA
     RQIRHPRQKL DEQRASIGKL AQTLSYSMKQ NLRAHTARFE RQTQALQHYR PDVSVCKNNI
     VRLQTALPAA FSQLLTHRRQ SLTAQAALLE AVSPQHILER GFSVVKNTRG QVIRNADVLK
     QGQKLHITFA DGETDVRVSK EQGQQDLFDC I