ID   EX7L_NEIMB              Reviewed;         451 AA.
AC   Q9JYZ2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=NMB1363;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AE002098; AAF41737.1; -; Genomic_DNA.
DR   PIR; D81092; D81092.
DR   RefSeq; NP_274381.1; NC_003112.2.
DR   RefSeq; WP_002225145.1; NC_003112.2.
DR   AlphaFoldDB; Q9JYZ2; -.
DR   STRING; 122586.NMB1363; -.
DR   PaxDb; Q9JYZ2; -.
DR   EnsemblBacteria; AAF41737; AAF41737; NMB1363.
DR   KEGG; nme:NMB1363; -.
DR   PATRIC; fig|122586.8.peg.1706; -.
DR   HOGENOM; CLU_023625_2_0_4; -.
DR   OMA; WPAVRFE; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..451
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197863"
SQ   SEQUENCE   451 AA;  50080 MW;  28C5C55DDEA02471 CRC64;
     MSDFFHSDVL SVSELNAFAK SLLENHLAGL WIAGEVSNLT RAASGHYYFS LKDSRAQVRC
     AMFKGAAVRL AKPLKEGDHI EVSGKISIYE ARGEFQITVN EVRLKGLGQL YEAYERLKAQ
     LQAEGAFAAE RKKPLPVRPQ CIGIVTSLAA AALRDVVTTL KRRAPEIPVI VYPTPVQGAG
     SELQIAQAIK TASQRAECDV LIVCRGGGSI EDLWAFNEEP VVRAIESCTV PVVSGVGHET
     DFTLADFVAD MRAPTPTGAA ELVSPNRQES LHRLAQAQCR LKTVLEQRYF DASQKLDWLA
     RQIRHPRQKL DEQRASIGKL AQTLSYSMTQ NVRTHTARFE RQTQALKHCR PDVSVCKKNI
     DRFQTALSHA FHQLLTHRRQ SLTAQAALLE AVSPQHILER GFSVVKNTRG QVIRNADVLK
     QGQKLHIIFA DGETDVRVSK EQGQQDLFDC I