EX7L_OCEIH
ID EX7L_OCEIH Reviewed; 455 AA.
AC Q8EQ44;
DT 06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=OB1879;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; BA000028; BAC13835.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8EQ44; -.
DR SMR; Q8EQ44; -.
DR STRING; 221109.22777563; -.
DR PRIDE; Q8EQ44; -.
DR EnsemblBacteria; BAC13835; BAC13835; BAC13835.
DR KEGG; oih:OB1879; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OMA; WPAVRFE; -.
DR PhylomeDB; Q8EQ44; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..455
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000197864"
SQ SEQUENCE 455 AA; 52117 MW; 19743E5C3749E3C1 CRC64;
MKDKYLTVTA LTKYVKRKMD SDPHLRDIWL RGEISNFKHH SRGHMYLTIK DDSARIQAVM
FASSNRKLLF HPENGMNVLI RGEISVFEAY GQYQLYIHEM EPDGIGSLYQ AFEQLKERLH
KQGYFADEYK KPIPRYPKNI AVITSPTGAA IRDILTTMKR RYPSVKITVF PVLVQGNQAK
ASIARSIQQA DSLSYDVIIV GRGGGSIEEL WSFNEEEVAR AIFESKTPII SAVGHETDTT
ISDFVADLRA PTPTAAGELA VPSQVELLDK IEIQKRQLAR LLKQYISQHE TILHQLRQTY
AFKYPHQLVK QKEQELDSTM DNLQRRMKSK VSDDKLTHNH LIKRLSSQHP QRELRLAIDK
LRQLHSLQNK MMNNYLEQQS QRLYSQIDKL SLVNPLEIMK RGYALPYNED GALIKSVKHL
HINDTIQLRI ADGEVTGKVT AIKEANENGN EGSNV
