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EX7L_PARMW
ID   EX7L_PARMW              Reviewed;         387 AA.
AC   Q7U490;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=SYNW2181;
OS   Parasynechococcus marenigrum (strain WH8102).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Parasynechococcus; Parasynechococcus marenigrum.
OX   NCBI_TaxID=84588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH8102;
RX   PubMed=12917641; DOI=10.1038/nature01943;
RA   Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P.,
RA   Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T.,
RA   Dufresne A., Partensky F., Webb E.A., Waterbury J.;
RT   "The genome of a motile marine Synechococcus.";
RL   Nature 424:1037-1042(2003).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; BX569694; CAE08696.1; -; Genomic_DNA.
DR   RefSeq; WP_011129036.1; NC_005070.1.
DR   AlphaFoldDB; Q7U490; -.
DR   SMR; Q7U490; -.
DR   STRING; 84588.SYNW2181; -.
DR   PRIDE; Q7U490; -.
DR   EnsemblBacteria; CAE08696; CAE08696; SYNW2181.
DR   KEGG; syw:SYNW2181; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_2_1_3; -.
DR   OMA; WPAVRFE; -.
DR   OrthoDB; 1371775at2; -.
DR   Proteomes; UP000001422; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..387
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000303831"
SQ   SEQUENCE   387 AA;  43071 MW;  B9F7934914797BD5 CRC64;
     MSADRIPSFS VAELNTAIGN LLERGFAPRF LVEATVSRPQ LKKGHLWLTL TDGEASISAV
     AWASQLRQLR YRPEDGDGVT VVGKLNFWAA RASLNVQVLD IRPSLSTVLR QFELVRRRLE
     EAGLLDITRR RPLPRQPRTL AVLTSVPSSA LADMLRTASE RWPMTRLLVV PIPVQGSVAA
     RIREVLGRLA EEASALGLDA LVLARGGGSR EDLAVFDDED LCRDLAAFPV PVVTGLGHED
     DLTVADLVAD HRAATPTAAI VALLPDRHVA LRELQQQRQR LRELRSRWLE RQHQRLLDRR
     QALALLTPQR RLQQLRQQLE QRRALLRALS PQRWLKQGLA LVSNGQGMTI DGVKGVRKKD
     TLTLSFHDGS IETVVTQVRP QNSSSTP
 
 
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