EX7L_PSEAB
ID EX7L_PSEAB Reviewed; 459 AA.
AC Q02RT0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=PA14_15230;
OS Pseudomonas aeruginosa (strain UCBPP-PA14).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCBPP-PA14;
RX PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT combinatorial.";
RL Genome Biol. 7:R90.1-R90.14(2006).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000438; ABJ13038.1; -; Genomic_DNA.
DR RefSeq; WP_003137871.1; NZ_CP034244.1.
DR AlphaFoldDB; Q02RT0; -.
DR SMR; Q02RT0; -.
DR PRIDE; Q02RT0; -.
DR EnsemblBacteria; ABJ13038; ABJ13038; PA14_15230.
DR KEGG; pau:PA14_15230; -.
DR HOGENOM; CLU_023625_3_1_6; -.
DR OMA; WPAVRFE; -.
DR BioCyc; PAER208963:G1G74-1246-MON; -.
DR Proteomes; UP000000653; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..459
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000303809"
SQ SEQUENCE 459 AA; 51222 MW; 5E1FD765160E4920 CRC64;
MRNDPFQRLG LDREVLTVSQ LNQRARLLLE DVFPQVWVEG ELSNLARPAS GHVYFTLKDS
NAQIRCALFR QNALRVRQAL RDGLAVKVRG KISLFEGRGD YQLIADTVEP AGDGALRLAF
EALKEKLAGE GLFASERKRP LPAHPRRIGI VSSPSGAVIR DIISVFRRRA PQVELTLVPT
AVQGREAVAQ IVRALQLADR QGFDALILAR GGGSLEDLWC FNEEAVARAV AACATPIVSA
VGHETDVSIS DFVADVRAPT PSAAAELLAP NAGDLQQRLD GLRRRLVLRM RDQLLRERLR
LEGVARRLRH PGERLRQQAQ RLDDLDMRLR RAFERHLAVR HERLVRLETR LAAQHPGRTL
ALLRQKLDSL AARLPRAARE VLKDRRQHLE GLAQTLNVVS PLATLGRGYS ILLDERGRAI
RDAGQTQPGQ RLKARLAEGE LEVRVEDNHR TPVTLSLLD
