ID   EX7L_PSEAE              Reviewed;         459 AA.
AC   Q9HXL8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=PA3777;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; AE004091; AAG07164.1; -; Genomic_DNA.
DR   PIR; G83174; G83174.
DR   RefSeq; NP_252466.1; NC_002516.2.
DR   RefSeq; WP_003113813.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; Q9HXL8; -.
DR   SMR; Q9HXL8; -.
DR   STRING; 287.DR97_4093; -.
DR   PaxDb; Q9HXL8; -.
DR   PRIDE; Q9HXL8; -.
DR   EnsemblBacteria; AAG07164; AAG07164; PA3777.
DR   GeneID; 878333; -.
DR   KEGG; pae:PA3777; -.
DR   PATRIC; fig|208964.12.peg.3954; -.
DR   PseudoCAP; PA3777; -.
DR   HOGENOM; CLU_023625_3_1_6; -.
DR   InParanoid; Q9HXL8; -.
DR   OMA; WPAVRFE; -.
DR   PhylomeDB; Q9HXL8; -.
DR   BioCyc; PAER208964:G1FZ6-3848-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..459
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000197866"
SQ   SEQUENCE   459 AA;  51232 MW;  C0FAFB85D4174935 CRC64;
     MRNDPFQRLG LDREVLTVSQ LNQRARLLLE DVFPQVWVEG ELSNLARPAS GHVYFTLKDS
     NAQIRCALFR QNALRVRQAL RDGLAVKVRG KISLFEGRGD YQLIADTVEP AGDGALRLAF
     EALKEKLAGE GLFASERKRP LPAHPRRIGI VSSPSGAVIR DIISVFRRRA PQVELTLVPT
     AVQGREAVAQ IVRALQLADR QGFDALILAR GGGSLEDLWC FNEEAVARAV AACATPIVSA
     VGHETDVSIS DFVADVRAPT PSAAAELLAP NAGDLQQRLD GLRRRLVLRM RDQLLRERLR
     LEGVARRLRH PGERLRQQAQ RLDDLDMRLR RAFERQLAVR HERLVRLETR LAAQHPGRTL
     ALLRQKLDSL AARLPRAARE VLKDRRQRLE GLAQTLNVVS PLATLGRGYS ILLDERGRAI
     RDAGQTQPGQ RLKARLAEGE LEVRVEDNHR TPVTLSLLD