EX7L_PSEE4
ID EX7L_PSEE4 Reviewed; 459 AA.
AC Q1I5K4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=PSEEN4397;
OS Pseudomonas entomophila (strain L48).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=384676;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L48;
RX PubMed=16699499; DOI=10.1038/nbt1212;
RA Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C.,
RA Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P.,
RA Weissenbach J., Lemaitre B., Medigue C., Boccard F.;
RT "Complete genome sequence of the entomopathogenic and metabolically
RT versatile soil bacterium Pseudomonas entomophila.";
RL Nat. Biotechnol. 24:673-679(2006).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CT573326; CAK17081.1; -; Genomic_DNA.
DR RefSeq; WP_011535452.1; NC_008027.1.
DR AlphaFoldDB; Q1I5K4; -.
DR SMR; Q1I5K4; -.
DR STRING; 384676.PSEEN4397; -.
DR EnsemblBacteria; CAK17081; CAK17081; PSEEN4397.
DR KEGG; pen:PSEEN4397; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_6; -.
DR OMA; WPAVRFE; -.
DR OrthoDB; 1371775at2; -.
DR Proteomes; UP000000658; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..459
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000303810"
SQ SEQUENCE 459 AA; 51366 MW; B103D675263595B8 CRC64;
MIKDPFERLG LDREVLTVSQ LNGRARVLLE DVFRSVWVEG EISNLARPAS GHMYFTLKDS
GAQIRCALFR QNALRVRQAL RDGLAVRVRG KVSLFEGRGD YQLILDTVEP AGDGALRLAF
EALKEKLGAE GLFSTERKRP LPAHPQRIGI ITSPTGAVIR DIISVFRRRA PQVELNLIPT
AVQGREAINQ IVRALQMADR QGFDALILAR GGGSLEDLWC FNEEAVARAV AACVTPIVSA
VGHETDVSIS DFVADVRAPT PSAAAELLAP DSSGLQQRLD SLQRRLLLRM QSRLAHDRLR
VEGLARRLRH PGERLRQQAQ RLDDLDMRLR RAFALNMNQR HERLGRLDTR LAAQHPGRSL
KLLKQRLDSL AERLPKAMRD VLKDRRQRFQ AQLQTLQVVS PLATLARGYS ILLDEHGQAI
RSAAQTHNGQ RLTARLNEGE LKVRVEDNHQ TPVTLSLLD
