EX7L_PSEU2
ID EX7L_PSEU2 Reviewed; 463 AA.
AC Q4ZX12;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=Psyr_1259;
OS Pseudomonas syringae pv. syringae (strain B728a).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX NCBI_TaxID=205918;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B728a;
RX PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA Kyrpides N.C., Ivanova N., Lindow S.E.;
RT "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT syringae B728a and pv. tomato DC3000.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000075; AAY36310.1; -; Genomic_DNA.
DR RefSeq; YP_234348.1; NC_007005.1.
DR AlphaFoldDB; Q4ZX12; -.
DR SMR; Q4ZX12; -.
DR STRING; 205918.Psyr_1259; -.
DR EnsemblBacteria; AAY36310; AAY36310; Psyr_1259.
DR KEGG; psb:Psyr_1259; -.
DR PATRIC; fig|205918.7.peg.1291; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_6; -.
DR OMA; WPAVRFE; -.
DR Proteomes; UP000000426; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..463
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000273679"
SQ SEQUENCE 463 AA; 51691 MW; 06D82A92375ED7BE CRC64;
MMPDMIKDPF ARLGLDREVL TVSQLNGRAR VLLEDVFSSI WVEGEISNLS RPASGHVYFT
LKDSGAQVRC ALFRQSAARV RQALKDGLQV KVRGKVSLFE GRGDYQLILD TVEPAGDGAL
RLAFDALKAK LSDEGLFSAE RKVALPLHPQ RIGIISSPTG AVIRDIISVF RRRAPRVELT
LIPTAVQGRE AINQIVRALK LADSRGFDAL ILARGGGSLE DLWCFNEEAV ARAIDACVTP
IVSAVGHETD VSISDFVADV RAPTPSAAAE LLAPDSSDLH RRVDNLHRRL VSRMQDRLMR
ERLRLEGISR RLRHPGERLR QQSQRLDDLD MRLRRALEQT MHQRQLRLAH MQSRLAAQHP
GRTLAFLRQR LDALAERLPR AIREQIKARK LQLQSQVQTL NVVSPLATLG RGYSILLDER
GHAIRNAAQT QTGQRLTARL GEGELHVRVE DNHLTPVTLS LLD
