EX7L_RHIE6
ID EX7L_RHIE6 Reviewed; 526 AA.
AC B3PYF6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378};
GN OrderedLocusNames=RHECIAT_CH0000313;
OS Rhizobium etli (strain CIAT 652).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=491916;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIAT 652;
RA Gonzalez V., Acosta J.L., Santamaria R.I., Bustos P.,
RA Hernandez-Gonzalez I.L., Fernandez J.L., Diaz R., Flores M., Mora J.,
RA Palacios R., Davila G.;
RT "Genome diversity and DNA divergence of Rhizobium etli.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP001074; ACE89307.1; -; Genomic_DNA.
DR RefSeq; WP_012482328.1; NC_010994.1.
DR AlphaFoldDB; B3PYF6; -.
DR EnsemblBacteria; ACE89307; ACE89307; RHECIAT_CH0000313.
DR GeneID; 45955690; -.
DR KEGG; rec:RHECIAT_CH0000313; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_5; -.
DR OMA; LVWPVKV; -.
DR Proteomes; UP000008817; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR PANTHER; PTHR30008; PTHR30008; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
DR TIGRFAMs; TIGR00237; xseA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease.
FT CHAIN 1..526
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_1000122078"
FT REGION 496..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 57481 MW; 2625E43D2E98FFE5 CRC64;
MSNLFDSDSP TNLAEYSVSE LSGSIKRTVE TAFDQVRVRG EISGYRGPHS SGHAYFALKD
DRARIDAVIW KGTFSRLKFR PEEGMEVIAT GKVTTFPGSS KYQIVIETLE PAGAGALMAL
IEERKRKLGA EGLFDAARKK RLPFMPKVIG VVTSPTGAVI RDILHRISDR FPVHVLVWPV
KVQGEGAGDE VANAIRGFNA LEPGGAIARP DVLIVARGGG SLEDLWSFND EIVVRAAAES
RIPLISAVGH ETDWTLIDYA ADVRAPTPTG AAEMAVPVKA ELEAQATALA ARLQGCINRQ
MDQRRQSVRA LMRALPSLDQ LLALPRRRFD EAAAGLGRGL ELNTINKRRG FERVASHLRP
DVLSNRIAER RQLLNDRMAR AERTVERLLD RSKSRIDRAE AILASLPTRL KTQTDRGRER
LGNLTRHADT AIRHQLTRAR AELSAQDRVL QSLSYKNVLK RGYAVIRDED DRPVSQAAAL
SAGMGIAIEF ADGRVGAMTT EGGTPPAGAK KRSAKPADPT KQGSLF
