ID   EX7L_RHIEC              Reviewed;         526 AA.
AC   Q2KDI7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=RHE_CH00276;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC       insoluble oligonucleotides, which are then degraded further into small
CC       acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC         direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00378}.
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DR   EMBL; CP000133; ABC89099.1; -; Genomic_DNA.
DR   RefSeq; WP_011423661.1; NC_007761.1.
DR   AlphaFoldDB; Q2KDI7; -.
DR   STRING; 347834.RHE_CH00276; -.
DR   EnsemblBacteria; ABC89099; ABC89099; RHE_CH00276.
DR   KEGG; ret:RHE_CH00276; -.
DR   eggNOG; COG1570; Bacteria.
DR   HOGENOM; CLU_023625_3_1_5; -.
DR   OMA; LVWPVKV; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..526
FT                   /note="Exodeoxyribonuclease 7 large subunit"
FT                   /id="PRO_0000303812"
FT   REGION          497..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  57733 MW;  8DA7E52ED4463CA9 CRC64;
     MSNLFDSDSP TNLAEYSVSE LSGSIKRTIE TAFDQVRVRG EISGYRGPHS SGHAYFALKD
     DRARIDAVIW KGTFSRLKFR PEEGMEVIAT GKVTTFPGSS KYQIVIETLE PAGAGALMAL
     IEERKRRLGA EGLFDAARKK RLPFMPHVIG VVTSPTGAVI RDILHRISDR FPVHVLVWPV
     KVQGEGSGEE VANAIRGFNA LEPASAISRP DVLIVARGGG SLEDLWSFND EIVVRAAAES
     RIPLISAVGH ETDWTLIDYA ADVRAPTPTG AAEMAVPVKA ELEAQAAALA ARLQGCMNRQ
     MDQRRQSVRS LMRAFPSLDQ LLALPRRRFD EAAAGLGRGL ELNTINKRRG FERVIAHLRP
     DLLSGRISER RQMLNERMVR AERMVERLID RSASRVERAE AILASLPARL KAQTDRSRER
     LGNLTRHADT AIRHQLTRAR AELSAQDRVL QSLSYKNVLR RGYAVIRDED NRPVSQAAAL
     SAGMGIAIEF ADGRIGAMTT EGGTPPGGAK KRSTKPAEPT KQGSLF